{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T02:52:30Z","timestamp":1717210350726},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,2,17]],"date-time":"2013-02-17T00:00:00Z","timestamp":1361059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>) is a common inflammatory disorder with a higher prevalence among women than men. The pathogenesis of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> is still unclear, and its heredity is not well characterized. Maternal inheritance of mitochondrial <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> (mt<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>) indicates its importance in human ethnic group classification as well disease susceptibility. So, this study was conducted to find whether mt<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> haplogroup associates with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> susceptibility in Chinese, and determine the influence of C\u2010stretch structure of mt<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> on <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and methods<\/jats:title><jats:p>We sequenced three hypervariable regions of mt<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> from 242 patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> and 237 healthy controls. The association between mt<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> haplogroups and <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> is tested by chi\u2010square test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventeen kinds of haplogroups were identified, and the frequency of haplogroup B4 was significantly higher in control group than that of the <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> group (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.013, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>=0.429). In female samples, B4 declared even more significance (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.003, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>=0.296). Meanwhile, the haplotypes of C\u2010stretch in mt<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> did not have any significant difference between case\u2010control groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mitochondrial DNA haplogroup B4 might have a protective effect to <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>, and its protective effect resides predominantly in women. However, the association between C\u2010stretch haplotype and <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> susceptibility still needs more patients for evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12074","type":"journal-article","created":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T15:14:57Z","timestamp":1359126897000},"page":"62-68","source":"Crossref","is-referenced-by-count":2,"title":["Mitochondrial haplogroup B4 may be a protective factor to oral lichen planus susceptibility in Chinese"],"prefix":"10.1111","volume":"20","author":[{"given":"D","family":"Wu","sequence":"first","affiliation":[{"name":"Center for DNA Typing Forth Military Medical University Xi'an China"},{"name":"Department of Biochemistry and Molecular Biology Forth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Xijing Hospital Forth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for DNA Typing Forth Military Medical University Xi'an China"},{"name":"Department of Biochemistry and Molecular Biology Forth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Sun","sequence":"additional","affiliation":[{"name":"Center for DNA Typing Forth Military Medical University Xi'an China"},{"name":"Department of Biochemistry and Molecular Biology Forth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for DNA Typing Forth Military Medical University Xi'an China"},{"name":"Department of Biochemistry and Molecular Biology Forth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics School of Stomatology Forth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine School of Stomatology Forth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Forth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for DNA Typing Forth Military Medical University Xi'an China"},{"name":"Department of Biochemistry and Molecular Biology Forth Military Medical University Xi'an 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