{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T20:27:08Z","timestamp":1771792028001,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,2,24]],"date-time":"2013-02-24T00:00:00Z","timestamp":1361664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of our investigation is to reveal the association of interleukin\u20106 (<jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106<\/jats:italic>) and interleukin\u20106 receptor (<jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106R<\/jats:italic>) gene polymorphisms with chronic periodontitis in Northwestern Chinese Han Population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A case\u2013control study of 199 cases of chronic periodontitis patients and 216 healthy controls was performed. Genomic <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was isolated from whole venous blood, and four single nucleotide polymorphisms (<jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106<\/jats:italic> \u2212572\u00a0G\/C and \u22121363\u00a0G\/T, <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106R<\/jats:italic> \u2212183\u00a0G\/A and +48892 A\/C) were analysed using polymerase chain reaction, followed by restriction fragment length polymorphism analysis and sequencing methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> analyses showed that the distribution of the <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106<\/jats:italic> \u2212572\u00a0G\/C and <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106R<\/jats:italic> \u2212183\u00a0G\/A polymorphisms did not differ between patients and controls. The frequency of the <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106<\/jats:italic> \u22121363\u00a0G\/T genotype <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> was significantly increased chronic periodontitis cases (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.023, odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>)\u00a0=\u00a02.825 adjusted for gender and age.) The <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106R<\/jats:italic> +48892 A\/C polymorphisms genotype <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> was found to be protective against chronic periodontitis (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.004, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.318 adjusted for gender and age.). In addition, compared with the other haplotypes, haplotype A<jats:sub>+48892<\/jats:sub>A<jats:sub>\u2212183<\/jats:sub> was significantly associated with chronic periodontitis, with an odds ratio of 0.720 (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0235).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that the <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106<\/jats:italic> \u22121363\u00a0G\/T and <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106R<\/jats:italic> +48892 A\/C polymorphisms may contribute to genetic susceptibility to chronic periodontitis in Northwestern Chinese Han population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12075","type":"journal-article","created":{"date-parts":[[2013,1,29]],"date-time":"2013-01-29T11:59:23Z","timestamp":1359460763000},"page":"69-75","source":"Crossref","is-referenced-by-count":21,"title":["The association of <scp>IL<\/scp>\u20106 and <scp>IL<\/scp>\u20106R gene polymorphisms with chronic periodontitis in a Chinese population"],"prefix":"10.1111","volume":"20","author":[{"given":"H\u2010Y","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Science, Lanzhou University Lanzhou City Gansu Province China"},{"name":"Institute of Hematology Lanzhou General Hospital of PLA Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Science, Lanzhou University Lanzhou City Gansu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Science, Lanzhou University Lanzhou City Gansu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X\u2010D","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Science, Lanzhou University Lanzhou City Gansu Province 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