{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:17:54Z","timestamp":1790889474809,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,2,15]],"date-time":"2013-02-15T00:00:00Z","timestamp":1360886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the effect of perinatal exposure to low doses of genistein and\/or vinclozolin on submandibular salivary gland (<jats:styled-content style=\"fixed-case\">SSG<\/jats:styled-content>) development in juvenile and adult male rats and to establish a link with sweet preference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Female rats received orally (1\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup> body weight\/day) genistein and vinclozolin, alone or in combination, from the first gestational day up to weaning. Sweet preference was assessed at weaning and in adulthood in male offspring; submandibular glands were then collected to study the morphogenesis and <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression of steroid receptors, growth factors and taste related proteins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Exposure to genistein and\/or vinclozolin resulted in a higher saccharin intake on postnatal day 25 (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05) linked to a higher number of pro\u2010acinar cells (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01) and <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression of progesterone receptor, growth factors and gustine (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01). These increases disappeared in adulthood, but <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expressions of sex hormone receptors and growth factors were strongly repressed in all treated groups (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings confirm that the SSG are target for xenohormones and provide evidence that perinatal exposure to low doses of genistein and\/or vinclozolin could simultaneously disrupt not only the salivary gland prepubertal development and sweet intake but also endocrine gene <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression later in life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12078","type":"journal-article","created":{"date-parts":[[2013,1,27]],"date-time":"2013-01-27T19:31:42Z","timestamp":1359315102000},"page":"812-823","source":"Crossref","is-referenced-by-count":9,"title":["Perinatal xenohormone exposure impacts sweet preference and submandibular development in male rats"],"prefix":"10.1111","volume":"19","author":[{"given":"W","family":"Kouidhi","sequence":"first","affiliation":[{"name":"Research Unit n\u00b0 01\/UR\/08\u201007 Faculty of Medicine Tunis Tunis El Manar University Tunis Tunisia"},{"name":"UMR 1324 CSGA INRA Dijon France"},{"name":"UMR 6265 CSGA CNRS Dijon France"},{"name":"CSGA University of Burgundy Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Berg\u00e8s","sequence":"additional","affiliation":[{"name":"UMR 1324 CSGA INRA Dijon France"},{"name":"UMR 6265 CSGA CNRS Dijon France"},{"name":"CSGA University of Burgundy Dijon 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