{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T08:31:25Z","timestamp":1717921885929},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,28]],"date-time":"2013-02-28T00:00:00Z","timestamp":1362009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>Upper airway (<jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>) dilator muscles are critical for the maintenance of airway patency. Injury or fatigue to this group of muscles, as observed in patients with obstructive sleep apnoea (<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>) and animal models of <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>, may leave the <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content> susceptible to collapse. Although the mechanisms underlying respiratory muscle dysfunction are not completely understood, there is strong evidence suggesting a link between increased production of reactive oxygen species and altered muscle function. The aim of this study was to examine the effects of <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content><jats:sub>2<\/jats:sub><jats:styled-content style=\"fixed-case\">O<\/jats:styled-content><jats:sub>2<\/jats:sub> on rat sternohyoid muscle function <jats:italic>in vitro<\/jats:italic>. Sternohyoid contractile and endurance properties were examined at 35\u00b0C under control or hypoxic conditions. Studies were conducted in the presence of varying concentrations of <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content><jats:sub>2<\/jats:sub><jats:styled-content style=\"fixed-case\">O<\/jats:styled-content><jats:sub>2<\/jats:sub> (0, 0.01, 0.1 and 1\u00a0mM). Muscle function was also examined in the presence of antioxidants [desferoxamine (<jats:styled-content style=\"fixed-case\">DFX<\/jats:styled-content>), catalase] and the reducing agent dithiothreitol (<jats:styled-content style=\"fixed-case\">DTT<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content><jats:sub>2<\/jats:sub><jats:styled-content style=\"fixed-case\">O<\/jats:styled-content><jats:sub>2<\/jats:sub> decreased muscle endurance in a concentration\u2010dependent manner. This was partially reversed by catalase, <jats:styled-content style=\"fixed-case\">DFX<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DTT<\/jats:styled-content>. Our results suggest that oxidants may contribute to <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content> respiratory muscle dysfunction with implications for the control of <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content> patency <jats:italic>in vivo<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/odi.12084","type":"journal-article","created":{"date-parts":[[2013,2,15]],"date-time":"2013-02-15T17:41:05Z","timestamp":1360950065000},"page":"162-170","source":"Crossref","is-referenced-by-count":5,"title":["Hydrogen peroxide alters sternohyoid muscle function"],"prefix":"10.1111","volume":"20","author":[{"given":"CM","family":"Shortt","sequence":"first","affiliation":[{"name":"UCD School of Medicine and Medical Science, Health Sciences, University College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KD","family":"O'Halloran","sequence":"additional","affiliation":[{"name":"UCD School of Medicine and Medical Science, 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