{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:10:57Z","timestamp":1777461057555,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T00:00:00Z","timestamp":1363564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Oral lichen planus (OLP) is a prevalent cell\u2010mediated autoimmune disease of unknown etiology. Disruption in the Th1\/Th2 equilibrium has been suspected to contribute to the pathogenesis of OLP. In this study, we aimed at exploring, in OLP, the interactions between Th1\/Th2 cytokines and Golli\u2010MBP, a regulator of autogenic T cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Thirty\u2010six OLP patients aged 18\u201379 and nineteen control subjects aged 20\u201369 were enrolled in the dental clinics of Nanjing Medical University. OLP was diagnosed clinically and verified by histopathological examination. All subjects were free of other autoimmune diseases. Peripheral blood mononuclear cells (PBMC) and serum were collected from all subjects. Gene expression and protein levels of Golli\u2010MBP, IFN\u2010\u03b3 and IL\u20104 were measured, respectively, by semiquantitative reverse transcription polymerase chain reaction and enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>When compared with control, PBMC and serum from OLP patients exhibited a significantly higher expression and concentration of Golli\u2010MBP and IL\u20104 and lower levels of IFN\u2010\u03b3. A strong negative correlation (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.838, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.000) was detected between the ratio of IFN\u2010\u03b3\/IL\u20104 and Golli\u2010MBP gene expression in PBMCs of OLP patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data support a potential link between Golli\u2010MBP and the dysregulation of the Th1\/Th2 equilibrium in OLP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12090","type":"journal-article","created":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T21:07:02Z","timestamp":1361480822000},"page":"205-211","source":"Crossref","is-referenced-by-count":21,"title":["Interactions between Golli\u2010MBP and Th1\/Th2 cytokines in patients with oral lichen planus"],"prefix":"10.1111","volume":"20","author":[{"given":"M","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Anatomy and cell biology Rush University Medical Center Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Institute of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Sroussi","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Diagnostic Sciences College of Dentistry University of Illinois at Chicago Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Institute of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Institute of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Engineering &amp; Applied Science Washington University in St. Louis St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Institute of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.55.2.4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1987.tb00480.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.1996.0393"},{"key":"e_1_2_7_5_1","first-page":"519","article-title":"Oral lichen planus: a review","volume":"58","author":"Carrozzo 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