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Among them, gastrointestinal presentations include chronic diarrhea, abdominal pain, weight loss or failure to thrive in children; but extra\u2010intestinal manifestations are also common, and actually appear to be on the rise. They include a large variety of ailments, such as dermatitis Herpetiformis, anemia, short stature, osteoporosis, arthritis, neurologic problems, unexplained elevation of transaminases, and even female infertility. For the clinician interested in oral diseases, celiac disease can lead to delayed tooth eruption, dental enamel hypoplasia, recurrent oral aphthae. Diagnosing celiac disease requires therefore a high degree of suspicion followed by a very sensitive screening test: serum levels of the autoantibody anti\u2010tissue transglutaminase. A positive subject will then be confirmed by an intestinal biopsy, and will then be put on a strict gluten\u2010free diet, that in most cases will bring a marked improvement of symptoms. Newer forms of treatment which in the future will probably be available to the non\u2010responsive patients are currently being actively pursued.<\/jats:p>","DOI":"10.1111\/odi.12091","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T10:29:52Z","timestamp":1361874592000},"page":"635-641","source":"Crossref","is-referenced-by-count":19,"title":["Celiac disease"],"prefix":"10.1111","volume":"19","author":[{"given":"E","family":"Rivera","sequence":"first","affiliation":[{"name":"Section of Gastroenterology Hepatology and Nutrition Department of Pediatrics University of Chicago Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Assiri","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Faculty of Medicine King Khalid University Hospital King Saud University Riyadh Saudi 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