{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:14Z","timestamp":1787015954143,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T00:00:00Z","timestamp":1365120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The role of Th17 cells and associated cytokines was investigated in oral lichen planus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>\n                      14 consecutive patients with oral lichen planus were investigated. For biological studies, tissues were taken from reticular or erosive lesions and from normal oral mucosa (controls) of the same patient.\n                      <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                      expression for IL\u201017F, IL\u201017A, MCP\u20101, IL\u201013, IL\u20102, IL\u201010, IL\u20101\u03b2, RANTES, IL\u20104, IL\u201012B, IL\u20108, IFN\u2010\u03b3, TNF\u2010\u03b1, IL\u20101\u03b1, IL\u201018, TGF\u2010\u03b21, IL\u201023R, IL\u20107, IL\u201015, IL\u20106, MIG, IP\u201010, LTB, VEGF, IL\u20105, IL\u201027, IL\u201023A, GAPDH, PPIB, Foxp3, GATA3, and RORC was measured using the QuantiGene 2.0.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Results showed that Th17\u2010type and Th0\u2010type molecules'\n                      <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                      s, when compared with results obtained from tissue controls, were increased in biopsies of erosive lesions, whereas Th2\u2010type molecules'\n                      <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                      s were increased in reticular lesions. When the CD4+ T\u2010cell clones, derived from oral lichen planus tissues and tissue controls, were analyzed, a higher prevalence of Th17 (confirmed by an increased CD161 expression) and Th0 CD4+ T clones was found in erosive lesions, whereas a prevalence of Th2 clones was observed in reticular lesions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data suggest that Th17, Th0, and Th2 cells, respectively, may have a role in the pathogenesis of erosive and reticular oral lichen planus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.12094","type":"journal-article","created":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T00:52:38Z","timestamp":1362531158000},"page":"212-218","source":"Crossref","is-referenced-by-count":81,"title":["Potential pathogenetic role of Th17, Th0, and Th2 cells in erosive and reticular oral lichen planus"],"prefix":"10.1111","volume":"20","author":[{"given":"M\u2010P","family":"Piccinni","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine Center of Excellence DENOTHE University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Lombardelli","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine Center of Excellence DENOTHE University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Logiodice","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine Center of Excellence DENOTHE University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Tesi","sequence":"additional","affiliation":[{"name":"Reference Center for the Study of Oral Diseases AUOC Careggi University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Kullolli","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine Center of Excellence DENOTHE University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Biagiotti","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine Center of Excellence DENOTHE University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MG","family":"Giudizi","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine Center of Excellence DENOTHE University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Romagnani","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine Center of Excellence DENOTHE University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Maggi","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine Center of Excellence DENOTHE University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Ficarra","sequence":"additional","affiliation":[{"name":"Reference Center for the Study of Oral Diseases AUOC Careggi University of Florence Florence 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