{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T16:39:36Z","timestamp":1768927176991,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T00:00:00Z","timestamp":1363824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>CD14<\/jats:italic><\/jats:styled-content> is a causative gene for periodontitis. However, conflicting results had been achieved when evaluating the associations between <jats:styled-content style=\"fixed-case\"><jats:italic>CD14<\/jats:italic><\/jats:styled-content> \u2212159 <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>&gt;<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> and periodontitis, which warranted us to conduct this meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A meta\u2010analysis based on eight relevant case\u2013control studies was conducted to address this issue. Odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) with 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s) were applied to test the association. The statistical heterogeneity across studies was assessed by Chi\u2010square\u2010based <jats:italic>Q<\/jats:italic>\u2010test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Retrieved studies regarding <jats:styled-content style=\"fixed-case\"><jats:italic>CD14<\/jats:italic><\/jats:styled-content> \u2212159 <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>&gt;<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> and periodontitis susceptibility were put into the final analysis. Overall and subgroup analyses were performed. Finally, we did not find that this polymorphism could contribute to modified risk of periodontitis or in stratified analysis by ethnicity and type of disease. However, this polymorphism was associated with decreased risk of mild to moderate periodontitis (<jats:styled-content style=\"fixed-case\">TT <\/jats:styled-content><jats:italic>vs <\/jats:italic><jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> OR<\/jats:styled-content>\u00a0=\u00a00.42, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a00.21\u20130.81, <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CC <\/jats:styled-content><jats:italic>vs <\/jats:italic><jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> OR<\/jats:styled-content>\u00a0=\u00a01.91, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.09\u20133.35) but not severe periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present meta\u2010analysis provided confirmative evidence that <jats:styled-content style=\"fixed-case\"><jats:italic>CD14<\/jats:italic><\/jats:styled-content> \u2212159 <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>&gt;<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> was involved in the development of periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12096","type":"journal-article","created":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T05:56:11Z","timestamp":1362549371000},"page":"805-811","source":"Crossref","is-referenced-by-count":10,"title":["Associations between <scp><i>CD14<\/i><\/scp> \u2212159 <scp>C<\/scp>&gt;<scp>T<\/scp> polymorphism and chronic\/aggressive periodontitis susceptibility"],"prefix":"10.1111","volume":"19","author":[{"given":"H","family":"Zhang","sequence":"first","affiliation":[{"name":"Xuzhou First People's Hospital Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"l","family":"Zhou","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Center for Disease Control and Prevention Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Han","sequence":"additional","affiliation":[{"name":"Institute of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q","family":"Cai","sequence":"additional","affiliation":[{"name":"Institute of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Pan","sequence":"additional","affiliation":[{"name":"Institute of Stomatology Nanjing Medical University Nanjing 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