{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:48:36Z","timestamp":1792100916000,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T00:00:00Z","timestamp":1365120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to analyse whether the polymorphisms of several pro\u2010 and anti\u2010inflammatory cytokines may influence the susceptibility to predominantly oral Mucous membrane pemphigoid (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>) in a Northern Italian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was obtained from 41 <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content> patients (29 with exclusively oral pemphigoid [<jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content>]) and 140 unrelated bone marrow donors. Thirteen cytokine genes with 22 single\u2010nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>) were studied by a sequence\u2010specific <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference between the patients taken together and healthy controls for any cytokine gene polymorphism studied. However, the allele A of the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104 receptor A (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) was significantly more frequent in <jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content> than controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), causing an increased frequency of genotype A\/A in <jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content> patients (89.7 <jats:italic>vs<\/jats:italic> 67.9, odds ratio: 4.11, 95% confidence intervals 1.18\u201314.28, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.023, Pc\u00a0=\u00a00.046).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u20101902 A\/A genotype has been associated with a reduced response to <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104 and has been found in 90% <jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content> patient. Giving the supposed importance of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104 in <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content> fibrotic process, our results can partially explain the low likelihood of scarring in <jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12106","type":"journal-article","created":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T07:02:55Z","timestamp":1363590175000},"page":"275-280","source":"Crossref","is-referenced-by-count":13,"title":["Interleukin\u20104<scp>RA<\/scp> gene polymorphism is associated with oral mucous membrane pemphigoid"],"prefix":"10.1111","volume":"20","author":[{"given":"M","family":"Carrozzo","sequence":"first","affiliation":[{"name":"Department of Oral Medicine Center for Oral Health Research School of Dental Sciences Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Dametto","sequence":"additional","affiliation":[{"name":"Transplantation Immunology Service Departments of Genetics, Biology and Biochemistry S. 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