{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T15:28:36Z","timestamp":1770132516601,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:00:00Z","timestamp":1366848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the pathological effects on temporomandibular joint cartilage of an experimentally created unilateral anterior crossbite prosthesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six\u2010week\u2010old female Sprague\u2013Dawley rats were divided into experimental and control groups and further divided into three subgroups for three time points (<jats:italic>n<\/jats:italic>\u00a0=\u00a09). In experimental groups, the unilateral anterior crossbite was created by bonding two metal tubes on left maxillary and mandibular incisors. 2, 4, or 8\u00a0weeks after operation, the histomorphological changes and the expression changes of <jats:styled-content style=\"fixed-case\">PCNA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> COL II<\/jats:styled-content>, aggrecan, <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20103, <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109, <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u201013, and <jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\u20101 in condylar cartilage were investigated by hematoxylin\u2013eosin and toluidine blue staining, real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>, and immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In experimental groups, decreasing in chondrocytes, cell\u2010free areas, reduction in the thickness of hypertrophic layer, and loss of extracellular matrix were noticed. The expression level of PCNA was decreased at week 2 and week 4. The <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression of COL II was decreased at 4\u00a0week and that of aggrecan was increased at 2\u00a0week but decreased at 4 and 8\u00a0week. The expression of MMP\u20109, MMP\u201013, and TIMP\u20101 was increased at 2\u2010week and decreased at 4\u2010 and 8\u2010week, while that of MMP\u20103 was increased at 4\u2010 and 8\u2010week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present unilateral anterior crossbite prosthesis led to degradation of mandibular condylar cartilage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12112","type":"journal-article","created":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T12:23:51Z","timestamp":1365423831000},"page":"301-306","source":"Crossref","is-referenced-by-count":58,"title":["Cartilage degradation in temporomandibular joint induced by unilateral anterior crossbite prosthesis"],"prefix":"10.1111","volume":"20","author":[{"given":"Y\u2010L","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Oral Anatomy and Physiology and TMD School of Stomatology Fourth Military Medical University Xi'an 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