{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:34:14Z","timestamp":1790616854464,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:00:00Z","timestamp":1366848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>External apical root resorption (<jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content>) is a frequent iatrogenic effect of orthodontic treatment. Substantial variability in responses to postorthodontic <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content> has been observed among patients even when similar treatment protocols were used. This observation suggests that environmental and\/or genetic variations between individuals may confer susceptibility or resistance to developing <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content>. The objective of this study is to determine whether variants in the osteopontin gene, an essential mediator in the odontoclast fusion and attachment process, are positively\/negatively associated with postorthodontic <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Genetic screening of eighty\u2010seven orthodontic patients was performed for two polymorphisms in the osteopontin gene cluster (rs9138 and rs11730582). Subjects were divided into groups, according to the presence or absence of <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content> (&gt;2\u00a0mm). Genotype distributions and allelic frequencies were calculated using the chi\u2010square test. Logistic regression analysis was used to assess the extent to which clinical\u2010related parameters interfered with the <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content>. Odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) and 95% confidence intervals were also calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from this study show that subjects heterozygous and homozygous for the most frequent allele of the osteopontin gene at position 89261521 [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 0.035 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.035*) (allele A)] and 89253600 [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 0.20 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.025*) (allele T)], respectively, are protected against postorthodontic <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content>. Nevertheless, a highly significant association was found in the comparative analysis of homozygous subjects [2\/2 (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>)] for the osteopontin gene (rs9138), resulting in an increased risk of suffering postorthodontic <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content>[<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 4.10; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.045*;<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 95%]. Subjects who were homozygous [2\/2 (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>)] for the osteopontin gene (rs11730582) were more likely, and to a greater extent, to be affected with <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content> [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 11.68; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.039*;<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 95%] compared with other genotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Variations in the osteopontin gene (rs9138 and rs11730582) are determinants of a genetic predisposition to suffer <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content> secondary to orthodontic treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12114","type":"journal-article","created":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T12:23:55Z","timestamp":1365423835000},"page":"307-312","source":"Crossref","is-referenced-by-count":27,"title":["Osteopontin gene <scp>SNP<\/scp>s (rs9138, rs11730582) mediate susceptibility to external root resorption in orthodontic patients"],"prefix":"10.1111","volume":"20","author":[{"given":"A","family":"Iglesias\u2010Linares","sequence":"first","affiliation":[{"name":"Department of Orthodontics School of Dentistry University of Seville Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RM","family":"Ya\u00f1ez\u2010Vico","sequence":"additional","affiliation":[{"name":"Department of Orthodontics School of Dentistry University of Seville Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AM","family":"Moreno\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Citology and Histology School of Medicine University of Seville Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Mendoza\u2010Mendoza","sequence":"additional","affiliation":[{"name":"Department of Paedriatic Dentistry School of Dentistry University of Seville Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Orce\u2010Romero","sequence":"additional","affiliation":[{"name":"Department of Orthodontics School of Dentistry University of Seville Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Solano\u2010Reina","sequence":"additional","affiliation":[{"name":"Department of Orthodontics School of Dentistry University of Seville Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200506"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mod.2003.42"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.10.012"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2007.10.051"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-5406(05)81763-9"},{"key":"e_1_2_6_7_1","first-page":"180","article-title":"Orthodontically induced inflammatory root resorption. Part II: the clinical aspects","volume":"72","author":"Brezniak N","year":"2002","journal-title":"Angle Orthod"},{"key":"e_1_2_6_8_1","first-page":"786","article-title":"A comparison of three methods to accurately measure root length","volume":"74","author":"Brezniak N","year":"2004","journal-title":"Angle Orthod"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21250"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI12980"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.9025"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.060315"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-8-428"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00138.2004"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00056-009-8808-6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001757"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-5406(97)70189-6"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-6343.2009.01458.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130401500205"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(83)90322-6"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01865.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.12.022"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2011.02.002"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1073-8746(99)80032-2"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2131"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-5406(05)81678-6"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(82)90317-7"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.7.4267"},{"key":"e_1_2_6_29_1","first-page":"1","article-title":"The genetic contribution to orthodontic root resorption: a retrospective twin study","volume":"20","author":"Ngan DC","year":"2004","journal-title":"Aust Orthod J"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10143"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-6343.2008.00432.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/19.1.149"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000020591"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-6343.2004.00286.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27400"},{"key":"e_1_2_6_36_1","volume-title":"Nonparametric statistics for the behavioural sciences","author":"Siegel S","year":"1988"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1086\/338920"},{"key":"e_1_2_6_38_1","first-page":"163","article-title":"External apical root resorption caused by orthodontic treatment: a review of the literature","volume":"12","author":"Topkara A","year":"2011","journal-title":"Eur J Paediatr Dent"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-419X(01)00037-3"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2009.06.021"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.12114","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.12114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T20:32:36Z","timestamp":1696278756000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.12114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,25]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/odi.12114"],"URL":"https:\/\/doi.org\/10.1111\/odi.12114","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,25]]}}}