{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:17:55Z","timestamp":1789834675250,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T00:00:00Z","timestamp":1370908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scientific Research from the Ministry of Education, Science, Sports and Culture","award":["24593005"],"award-info":[{"award-number":["24593005"]}]},{"name":"Saitama Medical University Internal","award":["10-01"],"award-info":[{"award-number":["10-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Masticatory muscle tendon\u2010aponeurosis hyperplasia is a new disease entity associated with limited mouth opening. In this study, we analyzed the microstructural characteristics of muscles and tendons in masticatory muscle tendon\u2010aponeurosis hyperplasia by electron microscopy and energy\u2010dispersive <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>\u2010ray analysis to determine the elemental composition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Histological analysis was performed to detect the calcification. Transmission electron microscopy and scanning electron microscopy were conducted to clarify the microstructural characteristics of muscles and tendons. Energy\u2010dispersive <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>\u2010ray microanalysis was performed to identify the distribution of elements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mineralized nodules were observed in tendon tissues of masticatory muscle tendon\u2010aponeurosis hyperplasia as compared with facial deformity. Electron microscopy revealed that the muscle and tendon tissues in masticatory muscle tendon\u2010aponeurosis hyperplasia showed degenerative changes and distinctive histological findings as compared with tissues in facial deformity. We found that <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>a, <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>i were detected only in masticatory muscle tendon\u2010aponeurosis hyperplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We demonstrated that masticatory muscle tendon\u2010aponeurosis hyperplasia exhibits heterotopic calcification in tendon tissues.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12140","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T07:57:39Z","timestamp":1369209459000},"page":"404-408","source":"Crossref","is-referenced-by-count":15,"title":["Masticatory muscle tendon\u2010aponeurosis hyperplasia exhibits heterotopic calcification in tendons"],"prefix":"10.1111","volume":"20","author":[{"given":"T","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Saitama Medical University Moroyama\u2010machi, Iruma\u2010gun Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Saitama Medical University Moroyama\u2010machi, Iruma\u2010gun Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Nakamoto","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Saitama Medical University Moroyama\u2010machi, Iruma\u2010gun Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Akita","sequence":"additional","affiliation":[{"name":"Division of Morphological Science Saitama Medical University Moroyama\u2010machi, Iruma\u2010gun Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Yoda","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery 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