{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T09:20:29Z","timestamp":1768555229384,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T00:00:00Z","timestamp":1372377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Approximately 40% of patients receiving conditioning chemotherapy prior to autologous hematopoietic stem cell transplants (a<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) develop severe oral mucositis (<jats:styled-content style=\"fixed-case\">SOM<\/jats:styled-content>). Aside from disabling pain, ulcerative lesions associated with <jats:styled-content style=\"fixed-case\">SOM<\/jats:styled-content> predispose to poor health and economic outcomes. Our objective was to develop a probabilistic graphical model in which a cluster of single\u2010nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) derived from salivary <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> could be used as a tool to predict <jats:styled-content style=\"fixed-case\">SOM<\/jats:styled-content> risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Salivary <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was extracted from 153 <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> patients and applied to Illumina <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ead<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hips. Using sequential data analysis, we filtered extraneous <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s, selected loci, and identified a predictive <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> network for <jats:styled-content style=\"fixed-case\">OM<\/jats:styled-content> risk. We then tested the predictive validity of the network using SNP array outputs from an independent <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified an 82\u2010<jats:styled-content style=\"fixed-case\">SNP B<\/jats:styled-content>ayesian network (<jats:styled-content style=\"fixed-case\">BN<\/jats:styled-content>) that was related to <jats:styled-content style=\"fixed-case\">SOM<\/jats:styled-content> risk with a 10\u2010fold cross\u2010validation accuracy of 99.3% and an area under the <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve of 99.7%. Using samples from a small independent patient cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a016), we demonstrated the network's predictive validity with an accuracy of 81.2% in the absence of any false positives.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>\u2010based <jats:styled-content style=\"fixed-case\">BN<\/jats:styled-content> developed from saliva\u2010sourced <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> can predict <jats:styled-content style=\"fixed-case\">SOM<\/jats:styled-content> risk in patients prior to a<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12146","type":"journal-article","created":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T12:23:31Z","timestamp":1370435011000},"page":"721-727","source":"Crossref","is-referenced-by-count":48,"title":["<scp>SNP<\/scp>\u2010based <scp>B<\/scp>ayesian networks can predict oral mucositis risk in autologous stem cell transplant recipients"],"prefix":"10.1111","volume":"19","author":[{"given":"ST","family":"Sonis","sequence":"first","affiliation":[{"name":"Inform Genomics Boston MA USA"},{"name":"Brigham and Women's Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JH","family":"Antin","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MW","family":"Tedaldi","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Alterovitz","sequence":"additional","affiliation":[{"name":"Inform Genomics Boston MA USA"},{"name":"Children's Medical Center Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200700422"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0210-128"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9503-z"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.06.012"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn923"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.5481"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng868"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.071571.107"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2012.00176"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1155"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781482286014"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.299"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.12.074"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781444300772"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052911"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1847"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1002\/(SICI)1097-0142(19980601)82:11<2275::AID-CNCR25>3.0.CO;2-Q","article-title":"The impact of mucositis on alpha\u2010hemolytic streptococcal infection in patients undergoing autologous bone marrow transplantation for hematologic malignancies","volume":"82","author":"Reuscher TJ","year":"1998","journal-title":"Cancer"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.20586"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.10.4182"},{"key":"#cr-split#-e_1_2_9_21_1.1","unstructured":"SchwartzbergL SonisS WalkerMet\u00a0al(2012).Single nucleotide polymorphism (SNP) Bayesian networks (BNs) predict risk of chemotherapy\u2010induced side effects in patients with breast cancer receiving dose dense"},{"key":"#cr-split#-e_1_2_9_21_1.2","unstructured":"(DD) Doxorubicin\/cyclophosphamide plus paclitaxel (AC+T). 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