{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:48:24Z","timestamp":1770752904924,"version":"3.50.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T00:00:00Z","timestamp":1373414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the plasma and saliva levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 in patients with bisphosphonate\u2010related osteonecrosis of the jaws (<jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content>) and to investigate whether there is a correlation between more advanced stages of <jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content> and levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>We studied three groups: group 1 consisted of 30 patients with <jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content> due to intravenous bisphosphonates (iv<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>), group 2 consisted of 25 patients treated with iv<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> but without <jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content>, and group 3 consisted of 15 healthy controls. In each case, we assayed plasma and saliva <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 samples using an <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly, higher <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 values were found in both saliva and plasma in group 1 <jats:italic>vs<\/jats:italic> groups 2 and 3 (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01). Group 1 showed no differences in plasma or saliva <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 according to patient gender (<jats:italic>P\u00a0<\/jats:italic>&gt;<jats:italic>\u00a0<\/jats:italic>0.05), type of tumor, <jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content> location, etiology of <jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content>, or disease stage (<jats:italic>P\u00a0<\/jats:italic>&gt;<jats:italic>\u00a0<\/jats:italic>0.05). We found higher plasma and saliva <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 values in the more advances stages of <jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content>, although the differences were not statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Plasma and saliva <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 values were higher in our patients with <jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content> than in controls and therefore might be a useful tool for monitoring the severity of BRONJ.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12150","type":"journal-article","created":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T07:26:42Z","timestamp":1372145202000},"page":"446-452","source":"Crossref","is-referenced-by-count":18,"title":["Interleukin\u20106 concentration changes in plasma and saliva in bisphosphonate\u2010related 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Maxillofacial Surgery University General Hospital Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MJ","family":"Terol","sequence":"additional","affiliation":[{"name":"Hematology Service of Oncohematology University Clinic Hospital Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Bagan","sequence":"additional","affiliation":[{"name":"Oral Medicine University of Valencia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JM","family":"Diaz\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgery University General Hospital Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Lluch","sequence":"additional","affiliation":[{"name":"Oncology Head Service of Oncohematology University Clinic Hospital Valencia 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