{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:30:15Z","timestamp":1790656215446,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003975","name":"Israel Cancer Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003975","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate serum levels of interleukin (IL)\u20101, IL\u20106, IL\u20108, IL\u201010, soluble IL\u20102 receptor (<jats:styled-content style=\"fixed-case\">sIL<\/jats:styled-content>\u20102R), squamous cell carcinoma antigen (<jats:styled-content style=\"fixed-case\">SCCA<\/jats:styled-content>), tissue polypeptide\u2013specific antigen (TPS) and vascular endothelial growth factor (<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>) in patients with potentially malignant disorders (PMD), oral squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>), or status\u2010post (<jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>) OSCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Blood was collected from 47 patients, either controls or diagnosed with <jats:styled-content style=\"fixed-case\">PMD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> OSCC<\/jats:styled-content>, or <jats:styled-content style=\"fixed-case\">SPOSCC<\/jats:styled-content>. Levels of cytokines and tumor marker were evaluated by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>s. Normal levels were based on previous studies and pathology determined by chi\u2010square and Fisher's exact tests. <jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Above normal levels of <jats:styled-content style=\"fixed-case\">SCCA<\/jats:styled-content> were found for <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content> and dysplasia patients (33.3% and 11.1%, respectively) and high range of normal (upper 20% of the normal range) for lichen planus, <jats:styled-content style=\"fixed-case\">SPOSCC<\/jats:styled-content>, and dysplasia patients (6.67%, 33.3%, and 22.2%, respectively), differences that approached statistical significance (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.055). No differences were found between groups for other tested markers. A progression was seen for <jats:styled-content style=\"fixed-case\">SCCA<\/jats:styled-content> from high range of normal in <jats:styled-content style=\"fixed-case\">SPOSCC<\/jats:styled-content> to a mixture of high normal and elevated in dysplasia to elevated in active <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>, suggesting that <jats:styled-content style=\"fixed-case\">SCCA<\/jats:styled-content> may be correlated with cancer progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher levels of serum <jats:styled-content style=\"fixed-case\">SCCA<\/jats:styled-content> may serve as a marker for dysplasia and progression to oral carcinogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12160","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T09:10:03Z","timestamp":1372756203000},"page":"477-481","source":"Crossref","is-referenced-by-count":20,"title":["Cytokines and tumor markers in 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