{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T14:17:17Z","timestamp":1783779437630,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T00:00:00Z","timestamp":1377734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Objective<\/jats:title>The aim of this study was to evaluate the frequency of micronuclei (MNs<\/jats:styled-content>) in both circulating lymphocytes and buccal epithelial cells of patients with oral lichenoid contact reactions (OLCRs<\/jats:styled-content>) or with oral lichen planus (OLP<\/jats:styled-content>) and compare their MN scores with those of healthy controls (HCs<\/jats:styled-content>).<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>The study group included 21 patients (mean age 51.3\u00a0\u00b1\u00a012.4; 6 males, 15 females) with OLCR<\/jats:styled-content>s and 22 patients (mean age 47.6\u00a0\u00b1\u00a014.4; 4 males, 18 females) with OLP<\/jats:styled-content> who were clinically diagnosed and histopathologically confirmed according to WHO<\/jats:styled-content> diagnostic criteria (WHO Collaborating Centre for Oral Precancerous Lesions, 1978). All patients with OLCR<\/jats:styled-content> demonstrated contact allergy to tested dental materials when evaluated by skin patch testing according to International Contact Dermatitis Research Group (ICDRG), while all OLP<\/jats:styled-content> patients tested negative to patch testing. Seventeen individuals with no oral mucosal disorders (mean age 51.7\u00a0\u00b1\u00a011.3; 8 males, 9 females) were recruited to constitute the healthy control group. [Correction added on 30 May 2014, after first online publication: the term, \u2018mean age\u2019 has been added to the text in parenthesis throughout the Material and Methods section.] Clinical features including type of OLP<\/jats:styled-content>, location, disease severity, presence of skin lesions, presence of systemic disease including any allergies and dental (periodontal) status were recorded. MN<\/jats:styled-content> analyses were performed on peripheral blood lymphocytes and on smears of buccal epithelial cells of all three study groups.<\/jats:p><\/jats:sec>Results<\/jats:title>Most OLP<\/jats:styled-content> and OLCR<\/jats:styled-content> lesions were of reticular type (83%), and OLP<\/jats:styled-content> lesions were distributed bilaterally on the buccal mucosa (90.5%). The medians of MN<\/jats:styled-content> frequencies in buccal epithelial cells in OLP<\/jats:styled-content> and OLCR<\/jats:styled-content> groups were significantly higher when compared with HC<\/jats:styled-content> group (P\u00a0<\/jats:italic><\u00a00.001). [Correction added on 30 May 2014, after first online publication: in the results, 2nd sentence, the word \u2018lymphocytes\u2019 has been removed.] There was no significant difference between OLP<\/jats:styled-content> group (14.5 range 3\u201395) and OLCR<\/jats:styled-content> group (16.0 range 3\u201393) in terms of median MN<\/jats:styled-content> frequencies in buccal epithelial cells (P<\/jats:italic>\u00a0=\u00a00.724) nor in peripheral lymphocytes between OLP<\/jats:styled-content> group (2.0 range 0\u20137) and OLCR<\/jats:styled-content> group (1.0 range 0\u20136) (P<\/jats:italic> = 0.92). [Correction added on 30 May 2014, after first online publication: (P<\/jats:italic> = 0.92) was wrongly placed after \u2018peripheral lymphocytes\u2019 and has now been shifted to the end of the last sentence.]<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Micronuclei scores do not distinguish OLP<\/jats:styled-content> from OLCR<\/jats:styled-content> when using buccal smears. OLP<\/jats:styled-content> and OLCR<\/jats:styled-content> both demonstrated significantly higher MN<\/jats:styled-content> frequencies in buccal cells, compared with healthy controls. MN<\/jats:styled-content> assessment in both buccal epithelial cells and circulating lymphocytes may serve as a potential biomarker tool for evaluating any cancer risk in OLP<\/jats:styled-content> and OLCR<\/jats:styled-content>. 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