{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:16:03Z","timestamp":1790126163442,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,9,23]],"date-time":"2013-09-23T00:00:00Z","timestamp":1379894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Periodontitis, mostly associated with <jats:italic>Porphyromonas gingivalis<\/jats:italic>, has frequently been related to adverse pregnancy outcomes. We therefore investigated whether lipopolysaccharides of <jats:italic>P.\u00a0gingivalis<\/jats:italic> (Pg\u2010<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>) induced pregnancy complications in the rat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Experiment 1: pregnant rats (day 14) received increasing Pg\u2010<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> doses (0.0\u201350.0\u00a0\u03bcg\u00a0kg<jats:sup>\u22121<\/jats:sup> bw; <jats:italic>n\u00a0<\/jats:italic>=\u00a02\/3 p per dose). Maternal intra\u2010aortic blood pressure, urinary albumin excretion, placental and foetal weight and foetal resorptions were documented. Experiment 2: 10.0\u00a0\u03bcg\u00a0kg<jats:sup>\u22121<\/jats:sup> bw (which induced the highest blood pressure together with decreased foetal weight in experiment 1) or saline was infused in pregnant and non\u2010pregnant rats (<jats:italic>n\u00a0<\/jats:italic>=\u00a07\/9 p per group). Parameters of experiment 1 and numbers of peripheral leucocytes as well as signs of inflammation in the kidney and placenta were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pg\u2010<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> infusion in pregnant rats increased maternal systolic blood pressure, reduced placental weight (dose dependently) and decreased foetal weight and induced foetal resorptions. It, however, did not induce proteinuria or a generalised inflammatory response. No effects of Pg\u2010<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> were seen in non\u2010pregnant rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pg\u2010<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> increased maternal blood pressure, induced placental and foetal growth restriction, and increased foetal resorptions, without inducing proteinuria and inflammation. Pg\u2010<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> may therefore play a role in pregnancy complications induced by periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12177","type":"journal-article","created":{"date-parts":[[2013,8,20]],"date-time":"2013-08-20T09:36:46Z","timestamp":1376991406000},"page":"591-601","source":"Crossref","is-referenced-by-count":31,"title":["The effect of <i>Porphyromonas gingivalis<\/i> lipopolysaccharide on pregnancy in the rat"],"prefix":"10.1111","volume":"20","author":[{"given":"A","family":"Kunnen","sequence":"first","affiliation":[{"name":"Department of Periodontology Center for Dentistry and Oral Hygiene University of Groningen University Medical Center Groningen Groningen The Netherlands"},{"name":"School of Health Care Studies Hanze University of Applied Sciences Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MG","family":"van Pampus","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Groningen University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JG","family":"Aarnoudse","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Groningen University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CP","family":"van der Schans","sequence":"additional","affiliation":[{"name":"School of Health Care Studies Hanze University of Applied Sciences Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Periodontology Center for Dentistry and Oral Hygiene University of Groningen University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MM","family":"Faas","sequence":"additional","affiliation":[{"name":"Division of Medical Biology Department of Pathology and Medical Biology University of Groningen University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2004.08.010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.7.4286"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.9.6035"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060362"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.11.067"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2004.09.007"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719111432871"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12074."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.62.10.4652-4655.1994"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)08049-0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000171121.31564.14"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(94)90463-4"},{"key":"e_1_2_8_14_1","first-page":"1510","article-title":"Glomerular inflammation in pregnant rats after infusion of low dose endotoxin. 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