{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:52:20Z","timestamp":1740124340915,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T00:00:00Z","timestamp":1382572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Guangdong Provincial Innovative Training Project","award":["1055812396"],"award-info":[{"award-number":["1055812396"]}]},{"DOI":"10.13039\/501100007162","name":"Guangdong Science and Technology Department","doi-asserted-by":"crossref","award":["2012B091100453"],"award-info":[{"award-number":["2012B091100453"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Sialolithiasis is a common disease caused by intraductal stones, formed by reduction in salivary flow, salivary stagnation, and metabolic events. We used computational fluid dynamics to investigate changes in salivary flow field around parotid stones of different shapes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Three\u2010dimensional configurations of the <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tensen's duct were reconstructed from computed tomography sialographic images. Fluid dynamics modeling was used to analyze the salivary flow field around stones under unstimulated and stimulated conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The majority of sialoliths were oval\u2010shaped (59\/98), followed by irregular (24\/98) and round (15\/98). Salivary velocity was significantly higher around streamlined stones, compared with round (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.013) and oval (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.025) types. Changes in salivary flow field around sialoliths were found to affect the pattern of mineral deposition in saliva. The area of low velocity around the round stone was double the size observed around the streamlined stone during the unstimulated state, whereas in the stimulated state, local vortexes were formed on the downstream side of round and oval stones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Salivary flow field around sialoliths plays an important role in the progression of multicentric stones, and analysis of the salivary dynamics during sialolithiasis may provide deeper understandings of the condition and aid in developing successful treatment strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12182","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T15:46:59Z","timestamp":1379000819000},"page":"624-630","source":"Crossref","is-referenced-by-count":6,"title":["Computational fluid dynamics analysis of salivary flow and its effect on sialolithogenesis"],"prefix":"10.1111","volume":"20","author":[{"given":"P","family":"Zhu","sequence":"first","affiliation":[{"name":"Guanghua School of Stomatology Hospital of Stomatology Sun Yat\u2010Sen University Guangdong Provincial Key Laboratory of Stomatology Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Lin","sequence":"additional","affiliation":[{"name":"Guanghua School of Stomatology Hospital of Stomatology Sun Yat\u2010Sen University Guangdong Provincial Key Laboratory of Stomatology Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Lin","sequence":"additional","affiliation":[{"name":"Guanghua School of Stomatology Hospital of Stomatology Sun Yat\u2010Sen University Guangdong Provincial Key Laboratory of Stomatology Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Xu","sequence":"additional","affiliation":[{"name":"Guanghua School of Stomatology Hospital of Stomatology Sun Yat\u2010Sen University Guangdong Provincial Key Laboratory of Stomatology Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"QY","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010HNS Case Western Reserve University Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Applied Mechanics and Engineering Sun Yat\u2010Sen University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2002.123863"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otot.2007.10.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(03)00227-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e3182108f4f"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrs.1812"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2010.238"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.9.951"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-009-9731-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2011.03.020"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2an15924d"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00258196"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2012.856"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2009.11.006"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318165e355"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2008.03.007"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2004.11.015"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23226"},{"key":"e_1_2_7_19_1","first-page":"145","article-title":"Causes 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