{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:03:32Z","timestamp":1780484612840,"version":"3.54.1"},"reference-count":59,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T00:00:00Z","timestamp":1383177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Orthodontic\u2010induced external apical root resorption (<jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content>) is a complex phenotype determined by poorly defined mechanical and patient intrinsic factors. The aim of this work was to construct a multifactorial integrative model, including clinical and genetic susceptibility factors, to analyze the risk of developing this common orthodontic complication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This retrospective study included 195 orthodontic patients. Using a multiple\u2010linear regression model, where the dependent variable was the maximum% of root resorption (%<jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content>max) for each patient, we assessed the contribution of nine clinical variables and four polymorphisms of genes involved in bone and tooth root remodeling (rs1718119 from <jats:italic>P2<jats:styled-content style=\"fixed-case\">RX<\/jats:styled-content>7<\/jats:italic>, rs1143634 from <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1B<\/jats:italic>, rs3102735 from <jats:italic><jats:styled-content style=\"fixed-case\">TNFRSF<\/jats:styled-content>11B<\/jats:italic>, encoding <jats:styled-content style=\"fixed-case\">OPG<\/jats:styled-content>, and rs1805034 from <jats:italic><jats:styled-content style=\"fixed-case\">TNFRSF<\/jats:styled-content>11A<\/jats:italic>, encoding <jats:styled-content style=\"fixed-case\">RANK<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical and genetic variables explained 30% of%<jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content>max variability. The variables with the most significant unique contribution to the model were: gender (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05), treatment duration (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001), premolar extractions (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01), Hyrax appliance (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) and <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> genotype of rs1718119 from <jats:italic>P2<jats:styled-content style=\"fixed-case\">RX<\/jats:styled-content>7<\/jats:italic> gene (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01). Age, overjet, tongue thrust, skeletal class <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and the other polymorphisms made minor contributions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study highlights the <jats:italic>P2<jats:styled-content style=\"fixed-case\">RX<\/jats:styled-content>7<\/jats:italic> gene as a possible factor of susceptibility to <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content>. A more extensive genetic profile may improve this model.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12185","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:36:04Z","timestamp":1381545364000},"page":"659-667","source":"Crossref","is-referenced-by-count":45,"title":["Polymorphisms of genes encoding <scp>P<\/scp>2<scp>X<\/scp>7R, <scp>IL<\/scp>\u20101<scp>B<\/scp>,<scp> OPG<\/scp> and <scp>RANK<\/scp> in orthodontic\u2010induced apical root resorption"],"prefix":"10.1111","volume":"20","author":[{"given":"S","family":"Pereira","sequence":"first","affiliation":[{"name":"Department of Orthodontics Faculty of Medicine University of Coimbra Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Lavado","sequence":"additional","affiliation":[{"name":"Department of Physics and Mathematics Polytechnic Institute of Coimbra (ISEC) Coimbra Portugal"},{"name":"Business Research Unit University Institute of Lisbon (ISCTE\u2010IUL) Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Medical Genetics Department Faculty of Medicine University of Coimbra Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Lopez","sequence":"additional","affiliation":[{"name":"Institute of Mechanical Engineering Faculty of Engineering University of Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Abreu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Faculty of Medicine University of Coimbra Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Silva","sequence":"additional","affiliation":[{"name":"Medical Genetics Department Faculty of Medicine University of Coimbra Coimbra Portugal"},{"name":"CIMAGO (Center of Investigation on Environmental, Genetics and 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