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Periodontitis is a host\u2010driven inflammatory response to a pathogenic bacterial biofilm in the subgingival environment, resulting in the progressive destruction of the tissues that support the teeth, specifically the gingiva, periodontal ligament and alveolar bone. This disease affects more than 50% of the population. Considering that radiation\u2010induced oral mucositis and periodontitis are both linked with continuing presence of systemic inflammation, they may be associated through a primed inflammatory response as proposed by the \u2018two\u2010hit\u2019 model. Alternatively, both conditions may be correlated as they represent a dysregulation of the inflammatory response. To date, no studies have looked into the association between these conditions. This review considers the current evidence that provides a rationale for proposing a link between periodontitis and oral mucositis.<\/jats:p>","DOI":"10.1111\/odi.12199","type":"journal-article","created":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T20:21:04Z","timestamp":1382473264000},"source":"Crossref","is-referenced-by-count":51,"title":["Radiation\u2010induced oral mucositis and periodontitis \u2013 proposal for an inter\u2010relationship"],"prefix":"10.1111","volume":"20","author":[{"given":"A","family":"Khaw","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences School of Dentistry University of Adelaide Adelaide SA Australia"},{"name":"Colgate Australian Clinical Dental Research Centre University of Adelaide Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Logan","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences School of Dentistry University of Adelaide Adelaide SA 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