{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:52:21Z","timestamp":1740124341549,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T00:00:00Z","timestamp":1384819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003820","name":"Hubei Population and Family Planning Commission","doi-asserted-by":"crossref","award":["JS-2010005"],"award-info":[{"award-number":["JS-2010005"]}],"id":[{"id":"10.13039\/501100003820","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Objective<\/jats:title>To explore the risk factors for CL<\/jats:styled-content>\/P<\/jats:styled-content> in H<\/jats:styled-content>ubei Province, C<\/jats:styled-content>hina.<\/jats:p><\/jats:sec>Methods<\/jats:title>A hospital\u2010based, matched case\u2013control study was conducted. One hundred and eight cases with CL<\/jats:styled-content>\/P<\/jats:styled-content> were matched by age and sex with 108 normal controls. Their parents were retrospectively interviewed using a questionnaire. Univariate and multivariate analyses were used to calculate the relative risk by odds ratio and 95% confidence interval.<\/jats:p><\/jats:sec>Results<\/jats:title>Univariate analysis identified ten factors as significantly related to CL<\/jats:styled-content>\/P (P<\/jats:italic>\u00a0<\u00a00.05). Multivariate conditional logistic regression models showed that five of these factors were significantly associated with CL<\/jats:styled-content>\/P<\/jats:styled-content>. Paternal occupational exposure (OR<\/jats:styled-content>\u00a0=\u00a013.08, 95% CI<\/jats:styled-content>: 2.35\u201372.86), first\u2010trimester maternal illness (OR<\/jats:styled-content>\u00a0=\u00a036.67, 95% CI<\/jats:styled-content>: 5.37\u2013250.36), first\u2010trimester maternal bad mood (OR<\/jats:styled-content>\u00a0=\u00a08.69, 95% CI<\/jats:styled-content>: 1.35\u201355.84), first\u2010trimester maternal diet of eggs or milk (\u22655 meals per week, OR<\/jats:styled-content>\u00a0=\u00a06.72, 95% CI<\/jats:styled-content>: 1.23\u201336.69), and first\u2010trimester maternal sexual activity (OR<\/jats:styled-content>\u00a0=\u00a05.98, CI<\/jats:styled-content> 95%:1.14\u201331.49) were risk factors for CL<\/jats:styled-content>\/P<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In our study, we identified that paternal occupational exposure, first\u2010trimester maternal illness, first\u2010trimester maternal bad mood, first\u2010trimester maternal diet of eggs or milk (\u22655 meals per week), and first\u2010trimester maternal sexual activities were significantly associated with increased CL<\/jats:styled-content>\/P<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12200","type":"journal-article","created":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T20:21:05Z","timestamp":1382473265000},"page":"31-37","source":"Crossref","is-referenced-by-count":4,"title":["Risk factors for non\u2010syndromic oral clefts: a matched case\u2013control study in H<\/scp>ubei Province, C<\/scp>hina"],"prefix":"10.1111","volume":"21","author":[{"given":"L","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Maternal and Children Health care School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Child Health Hubei Maternal and Children's Healthcare Hospital Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Maternal and Children Health care School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychology East China Normal University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Maternal and Children Health care School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Maternal and Children Health care School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Maternal and Children Health care School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Maternal and Children Health care School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan 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