{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T03:02:25Z","timestamp":1772506945183,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T00:00:00Z","timestamp":1385337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research, New Delhi","doi-asserted-by":"crossref","award":["5\/4\/2-5\/09-NCD-II"],"award-info":[{"award-number":["5\/4\/2-5\/09-NCD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Objective<\/jats:title>Cyclooxygenase\u20102 (COX<\/jats:styled-content>\u20102) enzyme is a major mediator of inflammation in periodontitis, leading to loss of gingival tissues and alveolar bone supporting the teeth. Previous studies have explored the role of COX<\/jats:styled-content>\u20102<\/jats:italic> polymorphisms with the risk of periodontitis in different ethnic groups; however, findings are inconsistent. So, we aimed to investigate the association of COX<\/jats:styled-content>\u20102<\/jats:italic> polymorphisms (rs20417, rs689466, and rs5275) in susceptibility to chronic periodontitis (CP<\/jats:styled-content>) in northern Indian population. Meta\u2010analysis was also carried out to precisely estimate the effect of COX<\/jats:styled-content>\u20102<\/jats:italic> polymorphisms in CP<\/jats:styled-content>.<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>Genotyping of COX<\/jats:styled-content>\u20102<\/jats:italic> polymorphisms was carried out through PCR<\/jats:styled-content>\u2010RFLP<\/jats:styled-content> in 200 CP<\/jats:styled-content> cases and 200 controls. For risk estimation, binary logistic regression was applied using SPSS<\/jats:styled-content>, version 15.0, while meta\u2010analysis was carried using MIX<\/jats:styled-content> 2.0 software.<\/jats:p><\/jats:sec>Results<\/jats:title>None of the COX<\/jats:styled-content>\u20102<\/jats:italic> polymorphisms independently were associated with the risk of CP<\/jats:styled-content>. Meta\u2010analysis suggested a significant reduced risk of CP<\/jats:styled-content> with rs5275+8473 C<\/jats:styled-content> allele and rs20417 in C<\/jats:styled-content>hinese population.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>No association was observed in any of the studied COX<\/jats:styled-content>\u20102<\/jats:italic> polymorphisms with CP<\/jats:styled-content> in N<\/jats:styled-content>orth I<\/jats:styled-content>ndia. But, the study should be replicated in larger sample size to arrive at a definitive conclusion. Meta\u2010analysis suggested a role of rs5275 COX<\/jats:styled-content>\u20102 polymorphisms in susceptibility to overall CP<\/jats:styled-content>, and on ethnic basis, rs20417 showed reduced risk of CP<\/jats:styled-content> in C<\/jats:styled-content>hinese population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12203","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T15:08:34Z","timestamp":1383232114000},"page":"38-45","source":"Crossref","is-referenced-by-count":14,"title":["COX<\/scp>\u20102<\/i> gene polymorphisms and risk of chronic periodontitis: a case\u2013control study and meta\u2010analysis"],"prefix":"10.1111","volume":"21","author":[{"given":"G","family":"Prakash","sequence":"first","affiliation":[{"name":"Department of Medical Genetics Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow 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