{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T05:42:47Z","timestamp":1696311767741},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T00:00:00Z","timestamp":1389571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The intravenous injection of bisphosphonates, currently used for osteoporosis, myeloma, or bone metastases, can cause <jats:styled-content style=\"fixed-case\">ONJ<\/jats:styled-content> especially in consequence of trauma. To avoid trauma during bisphosphonate treatment, preventive oral surgery is recommended. The research aimed to evidence whether inflammatory and osteoclastogenic factors are not induced in oral mucosa after bisphosphonate treatment in patients receiving oral preventive surgery procedure and whether proliferation factors are not inhibited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Specimens of oral mucosa were removed from healthy subjects and from patients undergoing preventive oral surgery before bisphosphonate treatment. The expression of cytokines and factors involved in osteoclast activity, cell proliferation, and angiogenesis were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cytokines and <jats:styled-content style=\"fixed-case\">RANK<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> levels decreased significantly in mucosa from patients undergoing preventive oral surgery procedure before bisphosphonate treatment in comparison with their levels at the beginning of procedure and also in comparison with the level in patients treated only with bisphosphonates and not developing <jats:styled-content style=\"fixed-case\">ONJ<\/jats:styled-content>; conversely, osteoprotegerin and hydroxymethylglutaryl coenzyme <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> reductase significantly increased or not changed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results suggest that preventive oral surgery could be able to prevent <jats:styled-content style=\"fixed-case\">ONJ<\/jats:styled-content> due to bisphosphonate treatment: The mucosa is not stimulated by bisphosphonates to cause <jats:styled-content style=\"fixed-case\">ONJ<\/jats:styled-content>, as bisphosphonates are probably not released from the bone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12215","type":"journal-article","created":{"date-parts":[[2013,12,14]],"date-time":"2013-12-14T12:54:44Z","timestamp":1387025684000},"page":"809-814","source":"Crossref","is-referenced-by-count":0,"title":["Preventive oral surgery before bisphosphonate administration to reduce osteonecrosis of the jaws"],"prefix":"10.1111","volume":"20","author":[{"given":"M","family":"Mozzati","sequence":"first","affiliation":[{"name":"SIOM Oral Surgery and Implantology Center Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Maggiora","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Scoletta","sequence":"additional","affiliation":[{"name":"Citt\u00e0 della Salute e della Scienza Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Vasta","sequence":"additional","affiliation":[{"name":"Oral Surgery Unit Dentistry Section Department of Surgical Sciences Dental School University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RA","family":"Canuto","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Muzio","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm442"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.11.003"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.01.040"},{"key":"e_1_2_8_5_1","first-page":"157","article-title":"Orofacial neurogenic pain and maxillofacial ischemic osteonecrosis","volume":"8","author":"Brotons A","year":"2003","journal-title":"Med Oral"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02976989"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01781.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22808"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22550"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-008-0484-3"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05835.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.03.050"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"e_1_2_8_14_1","volume-title":"Oral and intravenous bisphosphonate. Induced osteonecrosis of the jaws","author":"Marx RE","year":"2007"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2009.12.003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2010.2921"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-012-0800-7"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003474.pub2"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2009.10.003"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5037.2008.00331.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn526"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.410"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2004.02.004"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/jop.2006.2.1.7"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00004164"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-009-0294-0"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl298"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2012.01173.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.12.005"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr039"},{"key":"e_1_2_8_31_1","first-page":"8","article-title":"Role of the cholesterol biosynthetic pathway in osteoblastic differentiation","volume":"30","author":"Viccica G","year":"2007","journal-title":"J Endocrinol Invest"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00328-8"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-10-200605160-00009"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.12215","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.12215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:28:26Z","timestamp":1696224506000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.12215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,13]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1111\/odi.12215"],"URL":"https:\/\/doi.org\/10.1111\/odi.12215","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,13]]}}}