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In this study, we investigated the role of\n                    <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>\n                    7 in the lymph node metastasis of tongue carcinoma. Immunohistochemistry and Western blot revealed the expression of\n                    <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>\n                    7 in tongue\n                    <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>\n                    tissues and cell lines. In addition, we examined the expression of\n                    <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>\n                    21, a ligand of\n                    <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>\n                    7, in normal and diseased lymph nodes using immunohistochemistry and\/or real\u2010time\n                    <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\n                    . The\n                    <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>\n                    7 expression was significantly correlated with cervical lymph node metastasis, tumor staging, and histological grade (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    =\n                    <jats:italic>\u00a0<\/jats:italic>\n                    0.015, 0.040, and 0.015, respectively). The multivariate analysis showed that regional lymph node metastasis, the expression of\n                    <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>\n                    7, and\n                    <jats:styled-content style=\"fixed-case\">LVD<\/jats:styled-content>\n                    were the independent poor prognostic factors. Knockdown of\n                    <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>\n                    7 gene resulted in a significant inhibition of migration and invasion of\n                    <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>\n                    4 cells\n                    <jats:italic>in vitro<\/jats:italic>\n                    without affecting the proliferation and apoptosis of tumor cells. Also,\n                    <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>\n                    7 knockdown obviously inhibited cervical lymph node metastasis in an animal tumor model. Our study indicated that\n                    <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>\n                    7 may play an important role in progression of tongue\n                    <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>\n                    and could be a promising target for tongue\n                    <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>\n                    therapy.\n                  <\/jats:p>","DOI":"10.1111\/odi.12228","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T04:47:14Z","timestamp":1392612434000},"page":"123-131","source":"Crossref","is-referenced-by-count":23,"title":["Correlation between\n                    <scp>CCR<\/scp>\n                    7 expression and lymph node metastatic potential of human tongue carcinoma"],"prefix":"10.1111","volume":"21","author":[{"given":"X","family":"Xia","sequence":"first","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) &amp; Key Laboratory of Oral Biomedicine Ministry of Education School &amp; Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Liu","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) &amp; Key Laboratory of Oral Biomedicine Ministry of Education School &amp; Hospital of Stomatology Wuhan University Wuhan China"},{"name":"Department of Oral and Maxillofacial and Head and Neck Oncology School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Zhang","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) &amp; Key Laboratory of Oral Biomedicine Ministry of Education School &amp; Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Shang","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) &amp; Key Laboratory of Oral Biomedicine Ministry of Education School &amp; Hospital of Stomatology Wuhan University Wuhan China"},{"name":"Department of Oral and Maxillofacial and Head and Neck Oncology School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-5323(02)00127-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(00)00096-0"},{"key":"e_1_2_8_4_1","first-page":"6751","article-title":"CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo 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