{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:12:33Z","timestamp":1788869553783,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T00:00:00Z","timestamp":1396915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grant-in-Aid for Scientific Research","award":["21390528"],"award-info":[{"award-number":["21390528"]}]},{"name":"Grant-in-Aid for Scientific Research","award":["24390447"],"award-info":[{"award-number":["24390447"]}]},{"name":"Nihon University Graduate School of Dentistry","award":["10010105"],"award-info":[{"award-number":["10010105"]}]},{"name":"Nihon University Research Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Mesiodentes are usually found in the central position of the upper or lower jaw as supernumerary teeth. Here, we obtained 10 mesiodentes and three permanent teeth (\n                      <jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content>\n                      ) and separated the dental pulp (\n                      <jats:styled-content style=\"fixed-case\">DP<\/jats:styled-content>\n                      ) from these into crown and root portions. We then characterized and compared the isolated crown portion\u2010derived cells (crown cells) with root portion\u2010derived cells (root cells) using a range of\n                      <jats:italic>in vitro<\/jats:italic>\n                      assays.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      Crown cells and root cells were examined for cell surface marker expression, colony\u2010forming unit\u2010fibroblast (\n                      <jats:styled-content style=\"fixed-case\">CFU<\/jats:styled-content>\n                      \u2010F), cell proliferation, cell cycle characteristics and markers, and osteogenic and adipogenic differentiation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The proportion of\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      105\u2010positive cells (\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      105\n                      <jats:sup>+<\/jats:sup>\n                      cells) in the crown cells\n                      <jats:italic>vs<\/jats:italic>\n                      the root cells varied among the mesiodentes, but not among the\n                      <jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content>\n                      . When there were more\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      105\n                      <jats:sup>+<\/jats:sup>\n                      cells in the root cells than in the crown cells, the root cells showed higher\n                      <jats:styled-content style=\"fixed-case\">CFU<\/jats:styled-content>\n                      \u2010F, proliferation capacity, and osteogenic differentiation capacity. In contrast, when the crown cells contained more\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      105\n                      <jats:sup>+<\/jats:sup>\n                      cells than the root cells, the crown cells showed the higher\n                      <jats:styled-content style=\"fixed-case\">CFU<\/jats:styled-content>\n                      \u2010F, proliferation capacity, and osteogenic differentiation capacity. In addition, the sorted\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      105\n                      <jats:sup>+<\/jats:sup>\n                      cells showed higher\n                      <jats:styled-content style=\"fixed-case\">CFU<\/jats:styled-content>\n                      \u2010F and proliferation capacity than the sorted\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      105\n                      <jats:sup>\u2212<\/jats:sup>\n                      cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These results indicated that proportion of\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      105\n                      <jats:sup>+<\/jats:sup>\n                      cells is an effective means of characterizing\n                      <jats:styled-content style=\"fixed-case\">DP<\/jats:styled-content>\n                      \u2010derived cells in mesiodentes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.12234","type":"journal-article","created":{"date-parts":[[2014,3,8]],"date-time":"2014-03-08T08:22:05Z","timestamp":1394266925000},"source":"Crossref","is-referenced-by-count":11,"title":["Characterization of mesenchymal progenitor cells in crown and root pulp from human mesiodentes"],"prefix":"10.1111","volume":"21","author":[{"given":"M","family":"Sato","sequence":"first","affiliation":[{"name":"Nihon University Graduate School of Dentistry Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Toriumi","sequence":"additional","affiliation":[{"name":"Department of Anatomy Nihon University School of Dentistry Tokyo 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