{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:45:08Z","timestamp":1793144708232,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T00:00:00Z","timestamp":1398297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Agreement for Doctoral Education"},{"DOI":"10.13039\/100007212","name":"Region V\u00e4stra G\u00f6taland","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007212","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Swedish Dental Society"},{"DOI":"10.13039\/501100014552","name":"Adlerbertska Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014552","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005293","name":"Gothenburg Dental Society","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005293","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Biobanking and Molecular Resource Infrastructure of Sweden"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare oral manifestations in a Swedish cohort of patients with orofacial granulomatosis with or without Crohn\u2032s disease and to assess <jats:styled-content style=\"fixed-case\">NOD<\/jats:styled-content>2 polymorphisms in the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010nine patients with orofacial granulomatosis were included. Demographics, disease history, clinical features and concurrent Crohn\u2032s disease were recorded. <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was extracted from buccal swabs and examined for <jats:styled-content style=\"fixed-case\">NOD<\/jats:styled-content>2 variants Arg702Trp, Gly908Arg and Leu1007fsinsC, all previously linked to gastrointestinal Crohn\u2032s disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve of 29 patients were diagnosed with coexisting gastrointestinal Crohn\u2032s disease, and of whom 21 were males. Symptom duration was significantly longer for the orofacial granulomatosis group com\u2010pared to the group with coexisting Crohn\u2032s disease (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001). The orofacial granulomatosis patients also perceived their overall discomfort, aesthetic problems and social discomfort as more severe. No significant differences in the clinical presentation of oral lesions between the two groups were found. None of the patients with orofacial granulomatosis carried any of the <jats:styled-content style=\"fixed-case\">NOD<\/jats:styled-content>2 variations, whereas four of the 12 patients with coexisting Crohn\u2032s disease had a <jats:styled-content style=\"fixed-case\">NOD<\/jats:styled-content>2 variant (Arg702Trp).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The two patient groups had similar phenotypic characteristics but seemed to have genotypic differences regarding <jats:styled-content style=\"fixed-case\">NOD<\/jats:styled-content>2. The Swedish cohort differed in their clinical characteristics from patients reported in other geographical regions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12236","type":"journal-article","created":{"date-parts":[[2014,3,19]],"date-time":"2014-03-19T19:28:59Z","timestamp":1395257339000},"source":"Crossref","is-referenced-by-count":29,"title":["Characterisation of a Swedish cohort with orofacial granulomatosis with or without Crohn's disease"],"prefix":"10.1111","volume":"21","author":[{"given":"G","family":"Gale","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Oral Pathology Institute of Odontology The Sahlgrenska Academy University of Gothenburg G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"\u00d6stman","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Sahlgrenska Academy University of Gothenburg G\u00f6teborg 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Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Saalman","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Institute of Clinical Sciences The Sahlgrenska Academy University of Gothenburg G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Jontell","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Oral Pathology Institute of Odontology The Sahlgrenska Academy University of Gothenburg G\u00f6teborg 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