{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T22:48:06Z","timestamp":1788648486456,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T00:00:00Z","timestamp":1398297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association of miR\u2010499a genetic polymorphism with the risk of oral leukoplakia, oral submucous fibrosis (OSF), oral squamous cell carcinoma (OSCC), and clinicopathological outcomes of OSCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The genotyping of miR\u2010499a T&gt;C (rs3746444) using TagMan assay was conducted in two case\u2010control studies of 1549 subjects. miR\u2010499a\u20105p and miR\u2010499a\u20103p were assayed using stem\u2010loop RT\u2010PCR for 63 paired OSCC and adjacent normal tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>T\/C+C\/C genotypes [adjusted odds ratio (AOR) 1.84, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.032] and C allelic type (AOR 1.91, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.007) at miR\u2010499a T&gt;C were associated with an increased risk of BQ\u2010related OSF as compared to those with T\/T genotype or T allelic type, respectively. Conversely, T\/C+C\/C genotypes and C allelic type decreased the risk of OSCC, especially for non\u2010BQ\u2010related OSCC (for genotype: AOR 0.49, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.010; for allelic type: AOR 0.50, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.007). Additionally, downregulation of miR\u2010499a\u20105p was found in OSCC tissues (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) and correlated with the TT genotype (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The T\/C+C\/C genotypes of MiR\u2010499a may contribute to an increased risk of BQ\u2010related OSF, but a decreased risk of OSCC. miR\u2010499a T&gt;C influences the expression levels of miR\u2010499a\u20105p during the tumorigenesis of OSCC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12241","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T05:15:06Z","timestamp":1396415706000},"page":"195-206","source":"Crossref","is-referenced-by-count":39,"title":["The association between miR\u2010499a polymorphism and oral squamous cell carcinoma 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