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Periconceptional folic acid supplementation can significantly reduce the risk of<jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the role of folate and other factors in preventing<jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>by analyzing the health and socio\u2010demographic data collected from a population sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective case\u2013control study in which mothers with children with or without<jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>were evaluated for the following main parameters: nutritional factors, socio\u2010demographic characteristics, pregnancy and family history, use of folate, and counseling by healthcare professionals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Socio\u2010epidemiological analysis of the 80 participants, 40 in the case group and 40 in the control group, found a significant impact on the risk of<jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>related to economic and educational status. The mothers who had a diet rich in vegetables and white meat had a lower risk of having children with<jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>. A short interval between pregnancies, subsequent pregnancy while still breastfeeding, and family history also increased risk of<jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Limited family planning, diet low in folate, and inadequate use of folate during the periconceptional period and during the first trimester of pregnancy were demonstrated a potential correlation with a high incidence of<jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>in this study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12256","type":"journal-article","created":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T13:06:35Z","timestamp":1400072795000},"page":"240-247","source":"Crossref","is-referenced-by-count":24,"title":["The role of the folic acid to the prevention of orofacial cleft: an epidemiological study"],"prefix":"10.1111","volume":"21","author":[{"given":"RF","family":"Figueiredo","sequence":"first","affiliation":[{"name":"Post\u2010Graduation in Health Science Medical School Federal University of Mato Grosso Cuiaba MT Brazil"},{"name":"Cuiaba Emergency Hospital Cuiaba MT Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Department of Basic Science in Health Medical School Federal University of Mato Grosso Cuiaba MT Brazil"},{"name":"Department of Spinal Surgery Dr. Sulaiman Al Habib Medical Group Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Feguri","sequence":"additional","affiliation":[{"name":"Cuiaba Emergency Hospital Cuiaba MT Brazil"},{"name":"Medical School Varzea Grande University Varzea Grande MT Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Bieski","sequence":"additional","affiliation":[{"name":"Post\u2010Graduation in Health Science Medical School Federal University of Mato Grosso Cuiaba MT Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Mello","sequence":"additional","affiliation":[{"name":"Medical School Federal University of Mato Grosso Cuiaba MT Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Department of Statistics Federal University of Mato Grosso Cuiaba MT Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AS","family":"Damazo","sequence":"additional","affiliation":[{"name":"Department of Basic Science in Health Medical School Federal University of Mato Grosso Cuiaba MT Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.2.598S"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9926(200007)62:1<42::AID-TERA9>3.0.CO;2-U"},{"key":"e_1_2_9_4_1","unstructured":"ANVISA (Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria)(2002).Farinha ter\u00e1 \u00e1cido f\u00f3lico para combater anencefalia em beb\u00eas.Brasilia Brazil. 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