{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:05:00Z","timestamp":1782252300932,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T00:00:00Z","timestamp":1403654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001700","name":"the Ministry of Education, Culture, Sports, Science, and Technology of Japan","doi-asserted-by":"crossref","award":["26293430"],"award-info":[{"award-number":["26293430"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>K\u00fcttner tumour (<jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>), so\u2010called chronic sclerosing sialoadenitis, is characterised by concomitant swelling of the submandibular glands secondary to strong lymphocytic infiltration and fibrosis independent of sialolith formation. However, recent studies have indicated that some patients with <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content> develop high serum levels of IgG4 and infiltration of IgG4\u2010positive plasma cells, namely IgG4\u2010related dacryoadenitis and sialoadenitis (IgG4\u2010<jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>), so\u2010called Mikulicz's disease. The aim of this study was to clarify the clinical and pathological associations between <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content> and IgG4\u2010<jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Fifty\u2010four patients pathologically diagnosed with <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content> or chronic sialoadenitis were divided into two groups according to the presence or absence of sialolith (<jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>\u2010S (+) or <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>\u2010S (\u2212), respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in the clinical findings, including the mean age, sex and disease duration, between the two groups. All patients in the <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>\u2010S (+) group showed unilateral swelling without infiltration of IgG4\u2010positive plasma cells or a history of other IgG4\u2010related diseases (IgG4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>), while those in the <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>\u2010S (\u2212) group showed bilateral swelling (37.5%), strong infiltration of IgG4\u2010positive plasma cells (87.5%) and a history of other IgG4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content> (12.5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest an association between the pathogeneses of <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>\u2010S (\u2212) and IgG4\u2010<jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>, but not <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>\u2010S (+).<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12259","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T10:12:45Z","timestamp":1400667165000},"page":"257-262","source":"Crossref","is-referenced-by-count":19,"title":["Clinical relevance of <scp>K<\/scp>\u00fcttner tumour and <scp>I<\/scp>g<scp>G<\/scp>4\u2010related dacryoadenitis and sialoadenitis"],"prefix":"10.1111","volume":"21","author":[{"given":"S","family":"Furukawa","sequence":"first","affiliation":[{"name":"Section of Oral and Maxillofacial Oncology Division of Maxillofacial Diagnostic and Surgical Sciences Faculty of Dental Science Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Moriyama","sequence":"additional","affiliation":[{"name":"Section of Oral and Maxillofacial Oncology Division of Maxillofacial Diagnostic and Surgical Sciences Faculty of Dental Science Kyushu 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