{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:17:51Z","timestamp":1787015871685,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T00:00:00Z","timestamp":1407369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2014,11]]},"abstract":"\n Objectives<\/jats:title>\n \n The aim of this study was to elucidate the role of 6\u20106 bieckol (\n EB<\/jats:styled-content>\n 1) and pholorofucofuroeckol\u2010A (\n EB<\/jats:styled-content>\n 5) from brown seaweed marine algae (\n Eisenia bicyclis<\/jats:italic>\n ) on lipopolysaccharide (\n LPS<\/jats:styled-content>\n )\u2010induced inflammation in human dental pulp cells (\n HDPC<\/jats:styled-content>\n s).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The cytotoxicity of\n EB<\/jats:styled-content>\n 1 and\n EB<\/jats:styled-content>\n 5 was examined by\n MTT<\/jats:styled-content>\n assay on\n LPS<\/jats:styled-content>\n \u2010induced human dental pulp cells. Their role on expression of inflammatory, odontogenic, and osteogenic molecules was determined by Western blot analysis. The dentin mineralization was checked by alkaline phosphatase activity.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The five compounds from\n E.\u00a0bicyclis<\/jats:italic>\n have different structure with non\u2010cytotoxic in\n HDPC<\/jats:styled-content>\n s.\n EB<\/jats:styled-content>\n 1 and\n EB<\/jats:styled-content>\n 5 showed anti\u2010inflammatory properties and inhibited phosphorylated\u2010extracellular signal\u2010regulated kinase (p\u2010\n ERK<\/jats:styled-content>\n 1\/2) and phosphorylated\u2010c\u2010jun\n N<\/jats:italic>\n \u2010terminal kinases (p\u2010\n JNK<\/jats:styled-content>\n ) without any cytotoxicity. In particular,\n EB<\/jats:styled-content>\n 1 inhibited cyclooxygenase\u20102 (\n COX<\/jats:styled-content>\n \u20102) and p\u2010\n ERK<\/jats:styled-content>\n 1\/2 signaling, and\n EB<\/jats:styled-content>\n 5 inhibited only p\u2010\n ERK<\/jats:styled-content>\n 1\/2 signaling but not\n COX<\/jats:styled-content>\n \u20102. Both compounds inhibited nuclear factor kappa\u2010B (\n NF<\/jats:styled-content>\n \u2010\n \u03ba<\/jats:italic>\n B) translocation. Furthermore,\n EB<\/jats:styled-content>\n 1 and\n EB<\/jats:styled-content>\n 5 increased dentinogenic and osteogenic molecules, and dentin mineralized via alkaline phosphatase activity (\n ALP<\/jats:styled-content>\n ) in\n LPS<\/jats:styled-content>\n \u2010induced\n HDPC<\/jats:styled-content>\n s.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This study elucidates that\n EB<\/jats:styled-content>\n 1 and\n EB<\/jats:styled-content>\n 5 have different types of anti\u2010inflammatory property and help in dentin formation. Therefore, these compounds derived from marine algae of\n E.\u00a0bicyclis<\/jats:italic>\n may be used as selective therapeutic strategies for pulpitis and oral diseases.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/odi.12266","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T03:59:04Z","timestamp":1402631944000},"page":"827-832","source":"Crossref","is-referenced-by-count":21,"title":["Eckols reduce dental pulp inflammation through the\n ERK<\/scp>\n 1\/2 pathway independent of\n COX<\/scp>\n \u20102 inhibition"],"prefix":"10.1111","volume":"20","author":[{"given":"U","family":"Paudel","sequence":"first","affiliation":[{"name":"Department of Oral Biochemistry Institute of Oral Bioscience BK21 program School of Dentistry Chonbuk National University Jeonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u2010H","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Oral Biochemistry Institute of Oral Bioscience BK21 program School of Dentistry Chonbuk National University Jeonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u2010H","family":"Kwon","sequence":"additional","affiliation":[{"name":"Gyeongbuk Institute for Marine Bio\u2010Industry Uljin Korea"},{"name":"Food Science and Biotechnology Major Andong National University Andong Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u2010H","family":"Park","sequence":"additional","affiliation":[{"name":"Gyeongbuk Institute for Marine Bio\u2010Industry Uljin Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u2010S","family":"Yun","sequence":"additional","affiliation":[{"name":"Division of Biotechnology, College of Environmental & Biosource Science Chonbuk National University Jeonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u2010H","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics School of Medicine Chonbuk National University Jeonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u2010K","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Oral Biochemistry Institute of Oral Bioscience BK21 program School of Dentistry Chonbuk National University Jeonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03292.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-012-1116-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2010.01915.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050493"},{"key":"e_1_2_7_6_1","first-page":"15","article-title":"COX\u20101 and COX\u20102 tissue expression: implications and predictions","volume":"49","author":"Crofford 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