{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T17:26:09Z","timestamp":1704302769593},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T00:00:00Z","timestamp":1421020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the role of <jats:styled-content style=\"fixed-case\">PRDM<\/jats:styled-content>1, a key molecule for modulating the immune cells, in Warthin tumour (<jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>) pathogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and methods<\/jats:title><jats:p>Forty paraffin\u2010embedded parotid tissues of patients (mean age: 62.08\u00a0\u00b1\u00a011.90) with <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> were retrieved from the pathology archives of Qindu Hospital from January 2012 to December 2012. The <jats:styled-content style=\"fixed-case\">PRDM<\/jats:styled-content>1 expression was investigated in a cohort of <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> by immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PRDM<\/jats:styled-content>1 was expressed only on the epithelial component but not on ectopic lymphoid tissue of the tumour. Statistically, <jats:styled-content style=\"fixed-case\">PRDM<\/jats:styled-content>1 expression rates between <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> glandular epithelial cells (40\/40 cases) and the tumour\u2010adjacent tissues (0\/9\u00a0cases), and <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> germinal centres (0\/34 cases) and tonsil tissues (10\/10 cases) were significantly different (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">PRDM<\/jats:styled-content>1 expression appeared to play an essential role in <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> pathogenesis. A better understanding of it might give options for revealing possible novel management strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12294","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T15:56:37Z","timestamp":1412351797000},"page":"432-436","source":"Crossref","is-referenced-by-count":1,"title":["<scp>PRDM<\/scp>1 expression on the epithelial component but not on ectopic lymphoid tissues of Warthin tumour"],"prefix":"10.1111","volume":"21","author":[{"given":"Y","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Tangdu Hospital Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology Qindu Hospital Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pathology Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pathology Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Tangdu Hospital Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Tangdu Hospital Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Xun","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Tangdu Hospital Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1786"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/77861"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2008.01.015"},{"key":"e_1_2_8_5_1","first-page":"467","article-title":"PRDM1\/BLIMP\u20101 expression in multiple B and T\u2010cell lymphoma","volume":"91","author":"Garcia JF","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.212.199"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-174656"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2012.03.009"},{"key":"e_1_2_8_9_1","first-page":"2881","article-title":"Warthin's tumour is not an Epstein\u2013Barr virus related disease","volume":"19","author":"Heerden WF","year":"1999","journal-title":"Anticancer Res"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2007.01.003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000276917"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110658"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10065"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.26.021607.090241"},{"key":"e_1_2_8_15_1","first-page":"81","article-title":"Immunohistochemical study of Warthin's tumour with special regard to the germinal centre","volume":"3","author":"Masuda A","year":"1988","journal-title":"Histol Histopathol"},{"key":"e_1_2_8_16_1","first-page":"830","volume-title":"Sternberg' s diagnostic surgical pathology, fifth ed. 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