{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T06:48:41Z","timestamp":1757314121327},"reference-count":63,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T00:00:00Z","timestamp":1422835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the distribution of oral and maxillofacial pathologies (<jats:styled-content style=\"fixed-case\">OMFP<\/jats:styled-content>s) and its association with patient age in young\u2010 and middle\u2010aged adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Distribution of histopathologically diagnosed <jats:styled-content style=\"fixed-case\">OMFP<\/jats:styled-content>s (<jats:italic>n<\/jats:italic>\u00a0=\u00a0385) treated during 2007\u20132010 was recorded and the association with patient age was retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The main diagnostic categories included benign exophytic lesions (45.3%), white benign lesions (13.5%), potentially malignant lesions\/disorders (10.1%), intrabony lesions (9.8%), mucosal discoloration (7.8%), benign pigmented lesions (7.3%), chronic trauma\/inflammation (3.9%), and oral malignancy (2.1%). Potentially malignant lesions\/disorders as a diagnostic category were positively associated with age (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.07 for 1\u00a0year; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and specifically the diagnoses of oral lichen planus (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.04 for 1\u00a0year; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.037) and dysplastic changes (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.08 for 1\u00a0year; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.013) that comprised this category. Pigmented melanocytic lesions were negatively associated with age (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.94 for 1\u00a0year; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.039) as well as benign\/reactive exophytic lesions (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.98 for 1\u00a0year; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.038), the latter included the histopathological diagnosis of benign salivary gland pathologies (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.90 for 1\u00a0year; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provided baseline information regarding the distribution <jats:styled-content style=\"fixed-case\">OMFP<\/jats:styled-content>s among young\u2010 and middle\u2010aged adults. It is important to highlight the high frequency of potentially malignant lesions\/disorders and oral malignancy in young\u2010 and middle\u2010aged adults, as these lesions require lifelong follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12308","type":"journal-article","created":{"date-parts":[[2015,1,7]],"date-time":"2015-01-07T15:25:35Z","timestamp":1420644335000},"page":"493-500","source":"Crossref","is-referenced-by-count":7,"title":["Oral and maxillofacial pathologies in young\u2010 and middle\u2010aged adults"],"prefix":"10.1111","volume":"21","author":[{"given":"G","family":"Almoznino","sequence":"first","affiliation":[{"name":"Department of Oral Medicine Hebrew University\u2010Hadassah School of Dental Medicine Jerusalem Israel"},{"name":"Department of Oral Medicine Oral and Maxillofacial Center Tel\u2010Hashomer, Medical Corps Israel Defense Forces Tel Aviv 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