{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:54:32Z","timestamp":1788386072171,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T00:00:00Z","timestamp":1424908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study examined the single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) in high\u2010mobility group box 1 (<jats:italic><jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>1)<\/jats:italic> gene in patients with oral squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>) and oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The study was conducted on 93 patients with <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>, 53 patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>, and 100 controls, all Caucasians of the same ethnicity, matched by age. <jats:italic><jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>1<\/jats:italic> genotypes for 4 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s, 2262G\/A (rs1045411), 1177G\/C (rs3742305), 3814C\/G (rs2249825), and rs4540927, were assessed using TaqMan <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> Genotyping Assays, Applied Biosystems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:italic><jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>1<\/jats:italic> 1177<jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> genotype was associated with lymph\u2010node metastasis and tumor stage in <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>s (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0.016 and <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.030, respectively). Genotype 1177<jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> resulted in poorer recurrence\u2010free survival (<jats:styled-content style=\"fixed-case\">RFS<\/jats:styled-content>), <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.000. The 1177G\/C polymorphism was an independent predictor of <jats:styled-content style=\"fixed-case\">RFS<\/jats:styled-content> compared to <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> genotype, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.001. The three polymorphisms were in linkage disequilibrium (<jats:styled-content style=\"fixed-case\">LD<\/jats:styled-content>). The <jats:styled-content style=\"fixed-case\">AGC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GGC<\/jats:styled-content> haplotypes were associated with an increased oral cancer risk, determined over the haplotype odds ratios (<jats:styled-content style=\"fixed-case\">HOR<\/jats:styled-content>\u00a0=\u00a013.316, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.015, and <jats:styled-content style=\"fixed-case\">HOR<\/jats:styled-content>\u00a0=\u00a05.769, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.029, respectively). The <jats:styled-content style=\"fixed-case\">AGC<\/jats:styled-content> haplotype was related to erosive <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> progression to <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HOR<\/jats:styled-content>\u00a0=\u00a012.179, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>1<\/jats:italic> polymorphism 1177G\/C could be associated with tumor progression and recurrence\u2010free survival in patients with <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>. The haplotypes of <jats:italic><jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>1<\/jats:italic> gene might be associated with susceptibility to <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> progression to <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12318","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T07:03:26Z","timestamp":1422601406000},"page":"536-543","source":"Crossref","is-referenced-by-count":19,"title":["<i><scp>HMGB<\/scp>1<\/i> genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients"],"prefix":"10.1111","volume":"21","author":[{"given":"G","family":"Supic","sequence":"first","affiliation":[{"name":"Faculty of Medicine Military Medical Academy University of Defense Belgrade Serbia"},{"name":"Institute for Medical Research Military Medical Academy Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Kozomara","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Military Medical Academy University of Defense Belgrade Serbia"},{"name":"Clinic for Maxillofacial Surgery Military Medical Academy Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Zeljic","sequence":"additional","affiliation":[{"name":"Institute for Medical Research Military Medical Academy Belgrade Serbia"},{"name":"Faculty of Biology University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Stanimirovic","sequence":"additional","affiliation":[{"name":"School of Dental Medicine Clinic of Periodontology and Oral Medicine University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Magic","sequence":"additional","affiliation":[{"name":"School of Dental Medicine Clinic of Periodontology and Oral Medicine University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Surbatovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Military Medical Academy University of Defense Belgrade Serbia"},{"name":"Clinic for Anesthesiology Military Medical Academy Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Jovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Military Medical Academy University of Defense Belgrade Serbia"},{"name":"Clinic for Maxillofacial Surgery Military Medical Academy Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Magic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Military Medical Academy University of Defense Belgrade Serbia"},{"name":"Institute for Medical Research Military Medical Academy Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2012.01158.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1622"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1993.tb00134.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.8.5237"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.04.012"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i31.5144"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27894"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1996.0369"},{"key":"e_1_2_7_11_1","first-page":"3881","article-title":"Variation of HMGB1 expression in breast cancer","volume":"21","author":"Flohr AM","year":"2001","journal-title":"Anticancer Res"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/759626"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2008.01441.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.05.013"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2014.03.007"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2007.00854.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc6935"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.10.002"},{"key":"e_1_2_7_19_1","first-page":"445","article-title":"Co\u2010expression of receptor for advanced glycation end products and the ligand amphoterin associates closely with metastasis of colorectal cancer","volume":"10","author":"Kuniyasu H","year":"2003","journal-title":"Oncol Rep"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.07.016"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(98)80001-8"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4781(01)00243-3"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2003.01296.x"},{"key":"e_1_2_7_24_1","first-page":"1592","article-title":"Transcriptional activation of the human HMGB1 gene in cisplatin\u2010resistant human cancer cells","volume":"61","author":"Nagatani G","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2008.00894.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01563.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm058"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/15.7.622"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2006.01.003"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20021646"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12232"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00582.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-005-5050-6"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.12.009"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2391"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25572"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2011.07.075"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.12318","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.12318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T21:44:12Z","timestamp":1696283052000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.12318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,26]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/odi.12318"],"URL":"https:\/\/doi.org\/10.1111\/odi.12318","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,26]]}}}