{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T04:10:23Z","timestamp":1747714223091,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T00:00:00Z","timestamp":1428278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministry of Education, Science and Technological Development of the Republic of Serbia","doi-asserted-by":"crossref","award":["175021"],"award-info":[{"award-number":["175021"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The influence of experimental diabetes (alloxan, 100\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>) was studied on rabbit parotid gland function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Carbachol\u2010induced parotid secretion<jats:italic>in vivo,<\/jats:italic>and<jats:italic>in vitro<\/jats:italic>quantification of inducible nitric oxide synthase (<jats:styled-content style=\"fixed-case\">iNOS<\/jats:styled-content>)<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>expression, by real\u2010time<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>, and activity of superoxide dismutase (<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>) and total antioxidant capacity (<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>) in commercial colorimetric assays were measured in parotid glands of non\u2010diabetic and diabetic rabbits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Carbachol\u2010induced dose\u2010dependent increase in parotid secretion significantly reduced in diabetic rabbits. Functional studies in the presence of muscarinic receptor and nitric oxide synthase (<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>) antagonists revealed that in M<jats:sub>3<\/jats:sub>receptor\u2010mediated carbachol secretion, nitric oxide, deriving mainly from neuronal<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">nNOS<\/jats:styled-content>) in control, and<jats:styled-content style=\"fixed-case\">iNOS<\/jats:styled-content>in diabetic rabbits, was involved. Also, upregulation of<jats:styled-content style=\"fixed-case\">iNOS mRNA<\/jats:styled-content>expression and enhanced<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>activity and<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>were detected in diabetic glands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data suggest that decreased M<jats:sub>3<\/jats:sub>receptor\u2010mediated parotid secretion in diabetic rabbits appears to be due to alterations in<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>signaling, mainly due to<jats:styled-content style=\"fixed-case\">iNOS<\/jats:styled-content>induction, accompanied by elevated antioxidant response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12327","type":"journal-article","created":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T15:29:06Z","timestamp":1424359746000},"page":"634-640","source":"Crossref","is-referenced-by-count":1,"title":["Reduced muscarinic parotid secretion is underlain by impaired<scp>NO<\/scp>signaling in diabetic rabbits"],"prefix":"10.1111","volume":"21","author":[{"given":"J","family":"Roganovi\u0107","sequence":"first","affiliation":[{"name":"Department of Pharmacology in Dentistry School of Dental medicine University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LJ","family":"Djuki\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacology in Dentistry School of Dental medicine University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Kr\u0161ljak","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Dental medicine University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Tani\u0107","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Institute for Biological Research \u2018Sini\u0161a Stankovi\u0107\u2019 University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Stoji\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacology in Dentistry School of Dental medicine University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164110390243"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2006.034710"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2005.03.007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.1999.tb00362.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0577"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(93)90027-B"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0031-6997(24)01362-0","article-title":"International Union of Pharmacology. 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