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It also evaluated whether <jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content> modifies mechanical allodynia and orofacial hyperalgesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Wistar rats (\u00b1250\u00a0g) were divided into groups that received saline (<jats:styled-content style=\"fixed-case\">SAL<\/jats:styled-content>) or complete Freund's adjuvant (<jats:styled-content style=\"fixed-case\">CFA<\/jats:styled-content>, 50\u00a0<jats:italic>\u03bc<\/jats:italic>l) in the <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>, and that later underwent <jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content> (20\u00a0J\u00a0cm<jats:sup>\u22122<\/jats:sup>) at their <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> or not (groups <jats:styled-content style=\"fixed-case\">SAL<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SAL<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CFA<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">CFA<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content> was applied on days 3, 5, 7, and 9 after <jats:styled-content style=\"fixed-case\">SAL<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">CFA<\/jats:styled-content>. Mechanical allodynia was evaluated on days 1, 3, 5, 7, and 10; orofacial hyperalgesia was assessed on day 10. Gelatin zymography and <jats:italic>in situ<\/jats:italic> zymography aided quantification of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>s in the <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Low\u2010level laser therapy abolished the reduction in the mechanical orofacial threshold and the increase in orofacial rubbing during the orofacial formalin test induced by <jats:styled-content style=\"fixed-case\">CFA<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content> also decreased the <jats:styled-content style=\"fixed-case\">CFA<\/jats:styled-content>\u2010induced rise in the levels of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102 as well as the gelatinolytic activity in the <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low\u2010level laser therapy could constitute an adjuvant therapy to treat temporomandibular disorders and prevent inflammation\u2010induced alterations in the levels of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109 and in the gelatinolytic activity in <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12330","type":"journal-article","created":{"date-parts":[[2015,2,21]],"date-time":"2015-02-21T14:32:55Z","timestamp":1424529175000},"page":"652-658","source":"Crossref","is-referenced-by-count":19,"title":["Laser therapy reduces gelatinolytic activity in the rat trigeminal ganglion during temporomandibular joint inflammation"],"prefix":"10.1111","volume":"21","author":[{"given":"AC","family":"Desider\u00e1","sequence":"first","affiliation":[{"name":"Department of Morphology, Physiology and Basic Pathology of Dentistry School of Ribeir\u00e3o Preto University of S\u00e3o Paulo Ribeir\u00e3o Preto SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GC","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Psychobiology Graduate Program School of Philosophy, Science and Literature of Ribeir\u00e3o Preto University of S\u00e3o Paulo Ribeir\u00e3o Preto SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RF","family":"Gerlach","sequence":"additional","affiliation":[{"name":"Department of Morphology, Physiology and Basic Pathology of Dentistry School of Ribeir\u00e3o Preto University of S\u00e3o Paulo Ribeir\u00e3o Preto SP 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