{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:44:28Z","timestamp":1791301468150,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T00:00:00Z","timestamp":1428278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science","award":["22890126"],"award-info":[{"award-number":["22890126"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2015,7]]},"abstract":"Objective<\/jats:title>YKL<\/jats:styled-content>\u201040 is a chitin\u2010binding glycoprotein, the level of which increases in inflammatory diseases, diabetes mellitus (DM<\/jats:styled-content>), cardiovascular diseases, and tumors. Gingival crevicular fluid (GCF<\/jats:styled-content>) contains many proteins and markers of periodontitis. The purpose of this study was to investigate YKL<\/jats:styled-content>\u201040 level in GCF<\/jats:styled-content> from patients with periodontitis and DM<\/jats:styled-content> and the association between YKL<\/jats:styled-content>\u201040 level and chronic periodontitis (CP<\/jats:styled-content>) or DM<\/jats:styled-content>.<\/jats:p><\/jats:sec>Subjects and Methods<\/jats:title>The subjects were 121 patients with DM<\/jats:styled-content>, CP<\/jats:styled-content>, DM<\/jats:styled-content> and periodontitis (DM<\/jats:styled-content>\u2010P), and healthy subjects (H). GCF<\/jats:styled-content> was collected using paper strips after the sites for GCF<\/jats:styled-content> collection were clinically evaluated for probing depth (PD<\/jats:styled-content>), gingival index (GI<\/jats:styled-content>), and bleeding on probing (BOP<\/jats:styled-content>). YKL<\/jats:styled-content>\u201040 in GCF<\/jats:styled-content> was identified by Western blotting, and its level was determined by ELISA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>YKL<\/jats:styled-content>\u201040 was contained in GCF<\/jats:styled-content> samples from H, DM<\/jats:styled-content>, CP<\/jats:styled-content>, and DM<\/jats:styled-content>\u2010P sites, and its levels (amount and concentration) in CP<\/jats:styled-content> and DM<\/jats:styled-content>\u2010P were significantly higher than those in H and DM<\/jats:styled-content>. GCF YKL<\/jats:styled-content>\u201040 level significantly correlated with PD<\/jats:styled-content> and GI<\/jats:styled-content>, and its level in BOP<\/jats:styled-content>\u2010positive sites was significantly higher than that in BOP<\/jats:styled-content>\u2010negative ones.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>GCF YKL<\/jats:styled-content>\u201040 level was elevated in periodontitis, but not DM<\/jats:styled-content>. YKL<\/jats:styled-content>\u201040 in GCF<\/jats:styled-content> may be an inflammatory marker for periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12334","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T15:02:44Z","timestamp":1425481364000},"page":"667-673","source":"Crossref","is-referenced-by-count":14,"title":["YKL<\/scp>\u201040 level in gingival crevicular fluid from patients with periodontitis and type 2 diabetes"],"prefix":"10.1111","volume":"21","author":[{"given":"J","family":"Kido","sequence":"first","affiliation":[{"name":"Department of Periodontology and Endodontology Institute of Health Bioscience The University of Tokushima Graduate School Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Bando","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Diabetes Tokushima University Hospital Tokushima 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