{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T22:46:51Z","timestamp":1772578011535,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,7,19]],"date-time":"2015-07-19T00:00:00Z","timestamp":1437264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2015,10]]},"abstract":"Objectives<\/jats:title>The purpose of this study was to evaluate the association between vascular endothelial growth factor (VEGF<\/jats:styled-content><\/jats:italic>) polymorphisms and bisphosphonate\u2010related osteonecrosis of the jaw (BRONJ<\/jats:styled-content>) in the Korean population.<\/jats:p><\/jats:sec>Subjects and Methods<\/jats:title>Forty\u2010five individuals (2 men, 43 women; mean age: 68.7\u00a0\u00b1\u00a012.3\u00a0years) were recruited for this study. All visited the Yonsei University Dental Hospital for surgical intervention from January 2012 to January 2013 and had a history of bisphosphonate (BP<\/jats:styled-content>) administration (oral and\/or intravenous). Patients were allocated to case (n<\/jats:italic>\u00a0=\u00a026) or control (n<\/jats:italic>\u00a0=\u00a019) groups according to the patients' selection criteria. Association between three VEGF<\/jats:styled-content><\/jats:italic> single nucleotide polymorphisms (rs699947 (\u20102578 C>A), rs2010963 (\u2010634\u00a0G>C) and rs3025039 (+936 C>T)) and BRONJ<\/jats:styled-content> were investigated using multiple logistic regression analysis and Fisher's exact test where appropriate (\u03b1\u00a0<\/jats:italic>=\u00a00.05).<\/jats:p><\/jats:sec>Results<\/jats:title>The CC<\/jats:styled-content> homozygotes of rs2010963 and rs3025039 of VEGF<\/jats:styled-content><\/jats:italic> gene were associated with an increased risk of BRONJ<\/jats:styled-content> (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.04, 0.03, respectively). In haplotype analysis, no differences in haplotype C\u2010C (\u20102578\/\u2010634) and haplotype C\u2010C\u2010C (\u20102578\/\u2010634\/+936) were observed.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The CC<\/jats:styled-content> homozygotes of rs2010963 and rs3025039 polymorphisms in the VEG<\/jats:italic>F<\/jats:styled-content> gene were associated with an increased risk of BRONJ<\/jats:styled-content> in the Korean population. Further epidemiological cohort studies with a larger sample size would be required to confirm the suggestive correlations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12355","type":"journal-article","created":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T11:05:47Z","timestamp":1434625547000},"page":"866-871","source":"Crossref","is-referenced-by-count":20,"title":["Genetic association between VEGF<\/scp><\/i> polymorphisms and BRONJ<\/scp> in the Korean population"],"prefix":"10.1111","volume":"21","author":[{"given":"H","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Prosthodontics Oral Science Research Center Yonsei University College of Dentistry Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JH","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Oral Biology Yonsei University College of Dentistry Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u2010H","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Oral Science Research Center Yonsei University College of Dentistry Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u2010H","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Oral Science Research Center Yonsei University College of Dentistry Seoul 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