{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T05:48:48Z","timestamp":1695620928791},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T00:00:00Z","timestamp":1439942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["935\/12"],"award-info":[{"award-number":["935\/12"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the expression of the programmed cell removal markers, calreticulin (<jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>47, known to be involved in various autoimmune diseases, in patients with oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>), and to investigate the association with clinical behavior.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Biopsies of 78 patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> were included. The clinical data were collected from patients' charts. The expression of <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>47 was immunomorphometrically analyzed in the epithelial (<jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>ep, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>47ep) and inflammatory cells (<jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>inf, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>47inf), and the results were correlated with the clinical presentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The epithelial and inflammatory cells expressed <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> (2.83\u00a0\u00b1\u00a06.62 and 5.13\u00a0\u00b1\u00a03.72) and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>47 (7.92\u00a0\u00b1\u00a04.6 and 10.7\u00a0\u00b1\u00a07.16). The expressions of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>47ep and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>47inf were associated (<jats:italic>R<\/jats:italic>\u00a0=\u00a00.64, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0005) with one another. The expressions of <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>inf and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>47ep were higher in atrophic erosive forms (A\/<jats:styled-content style=\"fixed-case\">ELP<\/jats:styled-content>) than in the keratotic form of patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> (6.46\u00a0\u00b1\u00a00.76 and 9.38\u00a0\u00b1\u00a00.87 <jats:italic>vs<\/jats:italic> 4.2\u00a0\u00b1\u00a00.61 and 6.84\u00a0\u00b1\u00a00.91, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.021). The expression of <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>ep was associated with more localized lesions (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.009) and more abundant in males (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.049), and the expression of <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>inf was associated with the presence of skin lesions and symptoms (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.034 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.047, respectively). Only in A\/<jats:styled-content style=\"fixed-case\">ELP<\/jats:styled-content> patients, the expression of <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>ep was associated with high expression of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>47ep (<jats:italic>R<\/jats:italic>\u00a0=\u00a00.6, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004), where both <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>47ep and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>47inf were associated with lower age of the patients (<jats:italic>R<\/jats:italic>\u00a0=\u00a0\u22120.48, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03 and <jats:italic>R<\/jats:italic>\u00a0=\u00a0\u22120.54, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The pattern of expression of <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>47 in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> suggests a general programmed cell removal response in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>. Symptomatic patients may benefit from <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>47 targeted therapy in the future.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12361","type":"journal-article","created":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T05:45:25Z","timestamp":1438407925000},"page":"894-898","source":"Crossref","is-referenced-by-count":0,"title":["Programmed cell removal biomarkers calreticulin and <scp>CD<\/scp>47 implicated in oral lichen planus"],"prefix":"10.1111","volume":"21","author":[{"given":"I","family":"Allon","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Oral Medicine The Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Vered","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Oral Medicine The Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Hirshberg","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Oral Medicine The Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"S25e1","DOI":"10.1016\/j.tripleo.2006.11.001","article-title":"Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerations","volume":"103","author":"Al\u2010Hashimi I","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12188"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jebdp.2014.10.004"},{"key":"e_1_2_8_5_1","first-page":"3","article-title":"Oxidative stress in lichen planus","volume":"19","author":"Aly DG","year":"2010","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2011.04152.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.4.541"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(99)70116-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2015.00035"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001375"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3171"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1997.tb00453.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930400022954"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1986.tb00621.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.648220"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00519.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2005.00373.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2015.00015"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-016832"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2013.09.016"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0722.2001.00081.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.06.020"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300405"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2000.290804.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(03)00305-6"},{"key":"e_1_2_8_26_1","first-page":"E310","article-title":"Oral lichen planus and oral lichenoid lesions; 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