{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:49:08Z","timestamp":1790833748692,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T00:00:00Z","timestamp":1445644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF\u20102014R1A1A1003214"],"award-info":[{"award-number":["NRF\u20102014R1A1A1003214"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Oral lichen planus is a chronic inflammatory oral mucosal disease whose exact cause is unclear and which requires efficient diagnostic and therapeutic strategies. Identification of disease\u2010specific biomarkers in saliva is an easy, quick, and non\u2010invasive approach for molecular diagnosis. This study was designed to examine salivary exosomal micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s (mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s) that could be candidates for diagnosing and elucidating the pathogenesis of oral lichen planus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>We compared mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> profiles of salivary exosomes of patients with oral lichen planus with those of healthy controls. Saliva samples from 16 patients with oral lichen planus and eight healthy controls were divided into two sets and examined using mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> microarray analysis and TaqMan quantitative <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The three mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s identified (miR\u20104484, miR\u20101246, and miR\u20101290) were further validated. Of these, miR\u20104484 was significantly upregulated in the salivary exosomes of patients with oral lichen planus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study thus identifies a potential mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> biomarker for oral lichen planus and provides insight into the functions of mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s in the pathogenesis of oral inflammatory diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12374","type":"journal-article","created":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T16:43:04Z","timestamp":1442853784000},"page":"987-993","source":"Crossref","is-referenced-by-count":99,"title":["Diagnostic profiling of salivary exosomal micro<scp>RNA<\/scp>s in oral lichen planus patients"],"prefix":"10.1111","volume":"21","author":[{"given":"J\u2010S","family":"Byun","sequence":"first","affiliation":[{"name":"Department of Oral Medicine 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