{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T02:23:40Z","timestamp":1785291820876,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T00:00:00Z","timestamp":1448236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"grant-in-aid for Scientific Research from Japanese Society for the Promotion of Science","award":["23592781"],"award-info":[{"award-number":["23592781"]}]},{"name":"grant-in-aid for Scientific Research from Japanese Society for the Promotion of Science","award":["15K11327"],"award-info":[{"award-number":["15K11327"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To define the increased <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression of Bpifb1, a member of the bactericidal\/permeability\u2010increasing protein family, in parotid acinar cells from non\u2010obese diabetic (<jats:styled-content style=\"fixed-case\">NOD<\/jats:styled-content>) mice, an animal model for Sj\u00f6gren's syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Parotid acinar cells were prepared from female <jats:styled-content style=\"fixed-case\">NOD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">NOD<\/jats:styled-content>\/ShiJcl) mice with or without diabetes, as well as from control (C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6<jats:styled-content style=\"fixed-case\">JJ<\/jats:styled-content>cl) mice. Total <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> and homogenate were prepared from the parotid acinar cells. Embryonic <jats:styled-content style=\"fixed-case\">cDNA<\/jats:styled-content> from a Mouse <jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content><jats:sup>\u2122<\/jats:sup> Panel\u00a0I kit was used. The expression of <jats:italic>Bpifb1<\/jats:italic> was determined by <jats:styled-content style=\"fixed-case\">cDNA<\/jats:styled-content> microarray analysis, <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>, real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>, northern blotting and <jats:italic>in\u00a0situ<\/jats:italic> hybridization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The expression of Bpifb1 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> was high in parotid acinar cells from diabetic and non\u2010diabetic <jats:styled-content style=\"fixed-case\">NOD<\/jats:styled-content> mice at 5\u201350\u00a0weeks of age. Acinar cells in the C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mice had a low expression of Bpifb1 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> at an age &gt;8\u00a0weeks, but had a relatively high expression in the foetus and infantile stages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bpifb1 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> is upregulated in parotid acinar cells in <jats:styled-content style=\"fixed-case\">NOD<\/jats:styled-content> mice, but its expression is not\u00a0related to the onset of diabetes. These findings\u00a0suggest that high expression levels of <jats:italic>Bpifb1<\/jats:italic> might predict disease traits before the onset of autoimmunity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12377","type":"journal-article","created":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T13:03:48Z","timestamp":1444223028000},"page":"46-52","source":"Crossref","is-referenced-by-count":5,"title":["Upregulation of <i>Bpifb1<\/i> expression in the parotid glands of non\u2010obese diabetic mice"],"prefix":"10.1111","volume":"22","author":[{"given":"T.","family":"Nashida","sequence":"first","affiliation":[{"name":"Departments of Biochemistry The Nippon Dental University School of Life Dentistry at Niigata Chuo\u2010ku Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Departments of Anatomy The Nippon Dental University School of Life Dentistry at Niigata Chuo\u2010ku Niigata 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