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However, more and more research found that<jats:styled-content style=\"fixed-case\">CTSK<\/jats:styled-content>was expressed in more extensive cells, tissues, and organs. It may not only participate in regulating human physiological activity, but also be closely related to a variety of disease. In this review, we highlight the relationship between<jats:styled-content style=\"fixed-case\">CTSK<\/jats:styled-content>and oral and maxillofacial disorders on the following three aspects: oral and maxillofacial abnormities in patients with pycnodysostosis caused by<jats:italic><jats:styled-content style=\"fixed-case\">CTSK<\/jats:styled-content><\/jats:italic>mutations, oral and maxillofacial abnormities in<jats:italic>Ctsk<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>mice, and the role of<jats:styled-content style=\"fixed-case\">CTSK<\/jats:styled-content>in oral and maxillofacial diseases, including periodontitis, peri\u2010implantitis, tooth movement, oral and maxillofacial tumor, root resorption, and periapical disease.<\/jats:p>","DOI":"10.1111\/odi.12378","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T20:57:22Z","timestamp":1444769842000},"page":"109-115","source":"Crossref","is-referenced-by-count":24,"title":["The role of cathepsin K in oral and maxillofacial disorders"],"prefix":"10.1111","volume":"22","author":[{"given":"X","family":"Wen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Military Stomatology Department of Prosthodontics School of Stomatology The Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u2010z","family":"Yi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology Department of Oral Biology School of Stomatology The Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Stomatology Northwest Women's and Children's Hospital Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u2010h","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology Department of Oral and Maxillofacial Surgery School of Stomatology The Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Xue","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology Department of Oral Biology School of Stomatology The Fourth Military Medical University Xi'an Shaanxi China"},{"name":"Clinic of Oral Rare and Genetic Diseases School of Stomatology The Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23996"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1999.tb00069.x"},{"key":"e_1_2_9_4_1","first-page":"E633","article-title":"Pycnodysostosis. 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