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Prominent among these is oral hairy leukoplakia (\n                    <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>\n                    ), a previously unknown lesion of the mouth associated with Epstein\u2013Barr virus (\n                    <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\n                    ) and initially seen only in people with\n                    <jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content>\n                    , in the then\u2010recognized risk groups, or those shown to be\n                    <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                    positive. Subsequently, it became clear that the distribution of\n                    <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>\n                    extends well beyond the\n                    <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                    spectrum. In this brief review, we consider the clinical and histological features of\n                    <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>\n                    , discuss how it was discovered, explore its cause, diagnosis, relationship with\n                    <jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content>\n                    , pathogenesis, significance in\n                    <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\n                    biology, options for management, and how it changes with\n                    <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content>\n                    therapy.\n                  <\/jats:p>","DOI":"10.1111\/odi.12393","type":"journal-article","created":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T01:31:03Z","timestamp":1461547863000},"page":"120-127","source":"Crossref","is-referenced-by-count":61,"title":["Hairy leukoplakia; lessons learned: 30\u2010plus years"],"prefix":"10.1111","volume":"22","author":[{"given":"JS","family":"Greenspan","sequence":"first","affiliation":[{"name":"Department of Orofacial Sciences School of Dentistry University of California San Francisco San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Greenspan","sequence":"additional","affiliation":[{"name":"Department of Orofacial Sciences School of Dentistry University of California San Francisco San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Webster\u2010Cyriaque","sequence":"additional","affiliation":[{"name":"Department of Dental Ecology School of Dentistry University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1992.tb00095.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/89.5.683"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.07.444"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.06.081"},{"key":"e_1_2_7_6_1","first-page":"117","article-title":"Human papillomavirus and Epstein Barr virus in oral hairy leukoplakia among HIV positive Venezuelan patients","volume":"23","author":"Correnti M","year":"2009","journal-title":"Acta odontologica latinoamericana: AOL"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1997.tb00354.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1998.tb00248.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12470556"},{"key":"e_1_2_7_10_1","first-page":"69","article-title":"BHRF1, a viral homologue of the Bcl\u20102 oncogene, disturbs epithelial cell differentiation","volume":"10","author":"Dawson CW","year":"1995","journal-title":"Oncogene"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835c1244"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198906083202315"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1128\/jcm.28.12.2775-2778.1990","article-title":"Diagnosis of Epstein\u2010Barr virus infection in hairy leukoplakia by using nucleic acid hybridization and noninvasive techniques","volume":"28","author":"De Souza YG","year":"1990","journal-title":"J Clin Microbiol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(92)90070-7"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199101000-00016"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890260307"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10561"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199105000-00007"},{"key":"e_1_2_7_19_1","first-page":"148","article-title":"Oral lesions among HIV\u2010infected hemophiliacs. 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