{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T03:21:24Z","timestamp":1768447284129,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T00:00:00Z","timestamp":1461542400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["OHARA 1U01AI068636"],"award-info":[{"award-number":["OHARA 1U01AI068636"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to determine active periodontal disease status in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> and to determine the impact of periodontal disease resolution on <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this longitudinal cohort study, 73 <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive subjects received comprehensive dental care. <jats:styled-content style=\"fixed-case\">AAP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CDC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AAP<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">BGI<\/jats:styled-content> case definitions determined periodontal classification. Likelihood and frequency of moderate\/severe periodontal disease were assessed based on demographic variables. The influence of periodontal intervention was assessed at baseline, 12, and 24\u00a0months. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 was measured in a subset of subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the periodontal classifications, BGI demonstrated the highest percentage category improvement with the intervention (&gt;50%). Moderate\/severe periodontitis was positively associated with HIV regardless of race, smoking status, gender, income level, and age, and was associated with increased IL\u20106. At baseline, the majority of subjects had severe periodontal disease regardless of <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> status. Subjects with suppressed viral load at baseline demonstrated a significant improvement in <jats:styled-content style=\"fixed-case\">BGI<\/jats:styled-content> classification (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.026), increased <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 counts (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.027), and decreased <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 levels (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Periodontal inflammation was prevalent regardless of <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> status. In virologically suppressed subjects, the intervention decreased periodontitis with a concomitant <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 decrease and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 increase. These findings suggest a relationship between periodontal inflammation, oral microbial translocation, and <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> status.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12419","type":"journal-article","created":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T05:31:03Z","timestamp":1461562263000},"page":"87-97","source":"Crossref","is-referenced-by-count":28,"title":["Impact of periodontal intervention on local inflammation, periodontitis, and <scp>HIV<\/scp> outcomes"],"prefix":"10.1111","volume":"22","author":[{"given":"J","family":"Valentine","sequence":"first","affiliation":[{"name":"Department of Periodontology School of Dentistry University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Saladyanant","sequence":"additional","affiliation":[{"name":"Department of Dental Research School of Dentistry University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Ramsey","sequence":"additional","affiliation":[{"name":"Department of Dental Research School of Dentistry University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Blake","sequence":"additional","affiliation":[{"name":"Department of Dental Research School of Dentistry University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Morelli","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Southerland","sequence":"additional","affiliation":[{"name":"MeHarry School of Dentistry Medical College Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EB","family":"Quinlivan","sequence":"additional","affiliation":[{"name":"Institute of Global Health and Infectious Diseases School of Medicine University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Dental Research School of Dentistry University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAE","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology School of Medicine University of North Carolina at Chapel Hill Chapel Hill NC USA"},{"name":"Institute of Global Health and Infectious Diseases School of Medicine University of North Carolina at Chapel Hill Chapel Hill NC 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