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Dental infection could result in immune and inflammatory responses mediated by molecular and cellular events and tissue breakdown. The inflammatory response of dental pulp could be regulated by genetic and epigenetic events. Epigenetic modifications play a fundamental role in gene expression. The epigenetic events might play critical roles in the inflammatory process of dental pulp injury. Major epigenetic events include methylation and acetylation of histones and regulatory factors,\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    methylation, and small non\u2010coding\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    s. Infections and other environmental factors have profound effects on epigenetic modifications and trigger diseases. Despite growing evidences of literatures addressing the role of epigenetics in the field of medicine and biology, very little is known about the epigenetic pathways involved in dental pulp inflammation. This review summarized the current knowledge about epigenetic mechanisms during dental pulp inflammation. Progress in studies of epigenetic alterations during inflammatory response would provide opportunities for the development of efficient medications of epigenetic therapy for pulpitis.\n                  <\/jats:p>","DOI":"10.1111\/odi.12464","type":"journal-article","created":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T10:50:42Z","timestamp":1456138242000},"page":"22-28","source":"Crossref","is-referenced-by-count":51,"title":["Epigenetic regulation in dental pulp inflammation"],"prefix":"10.1111","volume":"23","author":[{"given":"T","family":"Hui","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu Sichuan China"},{"name":"Department of Biochemistry Rush University Medical Center Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases West China Hospital of 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