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Eleven patients received repeat evaluation and imaging after wearing a stabilization splint for 3\u00a0months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During teeth clench, the\n                      <jats:styled-content style=\"fixed-case\">TMD<\/jats:styled-content>\n                      s patients showed decreased positive activity in the left precentral gyrus, right and left inferior temporal gyrus, and left cerebellum and increased negative activations in the right medial prefrontal cortex (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05 after AlphaSim correction). The 11\n                      <jats:styled-content style=\"fixed-case\">TMD<\/jats:styled-content>\n                      s patients after treatment showed a return to normal neural activity in these areas. No brain areas in\n                      <jats:styled-content style=\"fixed-case\">TMD<\/jats:styled-content>\n                      s patients showed differences in activation after treatment compared with the controls, except for an increase in activation in the right cerebellum in the 11\n                      <jats:styled-content style=\"fixed-case\">TMD<\/jats:styled-content>\n                      s patients (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05 after AlphaSim correction).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Decreased activations in cerebral areas associated with motor and cognitive functions in\n                      <jats:styled-content style=\"fixed-case\">TMD<\/jats:styled-content>\n                      s patients during teeth clenching were observed. Normalized activations of these areas happened in patients after routine treatment. These findings may facilitate the understanding of\n                      <jats:styled-content style=\"fixed-case\">TMD<\/jats:styled-content>\n                      s pathogenesis and the therapeutic mechanisms of the stabilization splint.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.12465","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T22:24:28Z","timestamp":1456439068000},"page":"406-414","source":"Crossref","is-referenced-by-count":12,"title":["Altered neural activation pattern during teeth clenching in temporomandibular disorders"],"prefix":"10.1111","volume":"22","author":[{"given":"SS","family":"He","sequence":"first","affiliation":[{"name":"Department of Orthodontics State Key Laboratory of Oral Disease West China School of Stomatology Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Huaxi MR Research Center (HMRRC) West China Hospital of Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics State Key Laboratory of Oral Disease West China School of Stomatology Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics State Key Laboratory of Oral Disease West China School of Stomatology Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SJ","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Orthodontics State Key Laboratory of Oral Disease West China School of Stomatology Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XQ","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology Huaxi MR Research Center (HMRRC) West China Hospital of Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Lui","sequence":"additional","affiliation":[{"name":"Department of Radiology Huaxi MR Research Center (HMRRC) West China Hospital of Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QY","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Radiology Huaxi MR Research Center (HMRRC) West China Hospital of Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthodontics State Key Laboratory of Oral Disease West China School of Stomatology Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.0022-0337.2005.69.11.tb04023.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-010-2291-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.04.005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2009.01947.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpor.2008.08.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841851003702180"},{"key":"e_1_2_7_8_1","first-page":"301","article-title":"Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique","volume":"6","author":"Dworkin SF","year":"1992","journal-title":"J Craniomandib Disord"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12238"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512443366"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21363"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0135058100"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.07.067"},{"key":"e_1_2_7_14_1","first-page":"101","article-title":"Studies on function and dysfunction of the masticatory system. 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