{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T13:00:49Z","timestamp":1776085249409,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T00:00:00Z","timestamp":1459123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["20020130200148BA"],"award-info":[{"award-number":["20020130200148BA"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["11220110101121"],"award-info":[{"award-number":["11220110101121"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to investigate whether histamine H<jats:sub>4<\/jats:sub> receptor (H<jats:sub>4<\/jats:sub>R) antagonists could prevent experimental periodontitis (<jats:styled-content style=\"fixed-case\">EP<\/jats:styled-content>)\u2010induced histological, functional and inflammatory alterations in submandibular gland (<jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>), periodontal bone and gingiva.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Bilateral <jats:styled-content style=\"fixed-case\">EP<\/jats:styled-content> was induced for 2\u00a0weeks in anaesthetized male rats. The effect of systemic and local administration of H<jats:sub>4<\/jats:sub>R antagonists (<jats:styled-content style=\"fixed-case\">JNJ<\/jats:styled-content>7777120, <jats:styled-content style=\"fixed-case\">JNJ<\/jats:styled-content>10191584) on histopathology and functionality of <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>, bone loss and gingival inflammation was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The subcutaneous administration of <jats:styled-content style=\"fixed-case\">JNJ<\/jats:styled-content>7777120 prevented periodontitis\u2010induced <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content> histological injury, reducing vacuolization and apoptosis and additionally reversed the increased prostaglandin E2 (PGE2) levels in <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content> while it partially reversed the methacholine\u2010induced salivation reduction produced by periodontitis. <jats:styled-content style=\"fixed-case\">JNJ<\/jats:styled-content>7777120 attenuated bone loss and the increased <jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>2 levels and inflammatory infiltration in gingival tissue of rats with periodontitis. Finally, local administration of <jats:styled-content style=\"fixed-case\">JNJ<\/jats:styled-content>7777120 and <jats:styled-content style=\"fixed-case\">JNJ<\/jats:styled-content>10191584 was also beneficial for improving periodontal parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>H<jats:sub>4<\/jats:sub> receptor antagonists are able to ameliorate periodontitis\u2010induced injury on <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>, gingival tissue and bone structure, suggesting that pharmacological targeting of H<jats:sub>4<\/jats:sub>R could be an attractive strategy to improve periodontal health.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12467","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T14:44:17Z","timestamp":1456497857000},"page":"423-429","source":"Crossref","is-referenced-by-count":8,"title":["Pharmacological targeting of histamine H<sub>4<\/sub> receptor in periodontal 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