{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:05:25Z","timestamp":1791774325257,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate comparatively the influence of histopathological features on epithelial dysplasia (<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>) and the effectiveness in usage of <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> and binary grading systems in actinic cheilitis (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Cytological and architectural alterations established by <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> were evaluated in 107 cases of <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>. Epithelial dysplasia was graded using <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> and binary systems. The comparisons were performed using kappa, chi\u2010square, and phi coefficient tests (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most cases were classified as mild <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> (44.5%) in the <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> system and as low risk for malignant transformation (64.5%) in the binary system. There was a positive correlation between <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> and binary systems (<jats:italic>k<\/jats:italic>\u00a0=\u00a00.33; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0002). Loss of basal cell polarity (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) was associated with severity of <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> grade in the <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> system. Anisonucleosis (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), nuclear pleomorphism (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), anisocytosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03), cell pleomorphism (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) increased nuclear\/cytoplasm ratio (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), increased nuclear size (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), increased number of mitotic figures (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0006), and dyskeratosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.008) were associated with severity of <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> grade in the binary system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It seems that usage of binary <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> grading system in <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> may be more precise because there is correlation between many of cytological and some of architectural microscopic alterations with increased grade of <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12484","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T23:30:35Z","timestamp":1459380635000},"page":"523-529","source":"Crossref","is-referenced-by-count":28,"title":["A comparative study using WHO and binary oral epithelial dysplasia grading systems in actinic cheilitis"],"prefix":"10.1111","volume":"22","author":[{"given":"PR","family":"C\u00e2mara","sequence":"first","affiliation":[{"name":"Patologia Oral Faculdade de Odontologia Universidade Federal Fluminense (UFF) Nova Friburgo Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SN","family":"Dutra","sequence":"additional","affiliation":[{"name":"Oral Pathology Piracicaba Dental School State University of 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