{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T07:40:39Z","timestamp":1769845239884,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T00:00:00Z","timestamp":1469491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Interleukin\u20101 beta (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1B) pathway is a key player in orthodontic\u2010induced external apical root resorption (<jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content>). The aim of this work was to identify the genes related to the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1 pathway as possible candidate genes for <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content>, which might be included in an integrative predictive model of this complex phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Using a stepwise multiple linear regression model, 195 patients who had undergone orthodontic treatment were assessed for clinical and genetic factors associated with %<jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content>max (maximum %<jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content> value obtained for each patient). The four maxillary incisors and the two maxillary canines were assessed. Three functional single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) were genotyped: rs1143634 in <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1B<\/jats:italic> gene, rs315952 in <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">RN<\/jats:styled-content><\/jats:italic> gene, and rs1059703 in X\u2010linked <jats:italic><jats:styled-content style=\"fixed-case\">IRAK<\/jats:styled-content>1<\/jats:italic> gene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The model showed that four of the nine clinical variables and one <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> explained 30% of the %<jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content>max variability. The most significant unique contributions to the model were gender (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001), treatment duration (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), premolar extractions (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.003), Hyrax appliance (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001), and homozygosity\/hemizygosity for variant C from <jats:italic><jats:styled-content style=\"fixed-case\">IRAK<\/jats:styled-content>1<\/jats:italic> gene (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.018), which proved to be a protective factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">IRAK<\/jats:styled-content>1<\/jats:italic> polymorphism is proposed as a protective variant for <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12514","type":"journal-article","created":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T09:16:48Z","timestamp":1464859008000},"page":"658-664","source":"Crossref","is-referenced-by-count":28,"title":["<i><scp>IRAK<\/scp>1<\/i> variant is protective for orthodontic\u2010induced external apical root resorption"],"prefix":"10.1111","volume":"22","author":[{"given":"S","family":"Pereira","sequence":"first","affiliation":[{"name":"Department of Orthodontics Dentistry Area Faculty of Medicine University of Coimbra Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Medical Genetics Department Faculty of Medicine University of Coimbra Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Canova","sequence":"additional","affiliation":[{"name":"Department of 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