{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:17:49Z","timestamp":1791227869095,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T00:00:00Z","timestamp":1468454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>IgG4\u2010related disease (IgG4\u2010RD) has emerged as a new entity in the last decade. It comprises numerous conditions previously thought to be unrelated. Macroscopically, these diseases cause diffuse organ swelling and formation of pseudotumorous masses. Histopathologically, they are characterized by a lymphoplasmacytic infiltrate with increased IgG4+ plasma cells and storiform fibrosis. Despite rapid progress within the last years, our knowledge on these conditions is still fragmented. To date, more than forty organs have been reported to be included in IgG4\u2010RD, and salivary gland involvement is amongst the most common organs affected [IgG4\u2010related sialadenitis (IgG4\u2010RS)]. Interestingly, IgG4\u2010RS shares commonalities with Sj\u00f6gren's syndrome (SS), like glandular enlargement, sicca symptoms, arthralgias, hypergammaglobulinemia, hypocomplementemia, and circulating antinuclear antibodies. Nonetheless, they differ in that the incidence of anti\u2010Ro and anti\u2010La reactivity is not frequently found in patients with IgG4\u2010RS, their salivary glands are infiltrated by a large number of IgG4+ plasma cells and IgG4\u2010RS symptoms respond promptly to steroids. The aim of this review was to describe the clinical, serological, histopathological and pathophysiological aspects of IgG4\u2010RS in the context of IgG4\u2010RD and highlight the differences between IgG4\u2010RS and SS.<\/jats:p>","DOI":"10.1111\/odi.12526","type":"journal-article","created":{"date-parts":[[2016,6,18]],"date-time":"2016-06-18T14:32:45Z","timestamp":1466260365000},"page":"152-156","source":"Crossref","is-referenced-by-count":54,"title":["IgG4\u2010related sialadenitis and Sj\u00f6gren's syndrome"],"prefix":"10.1111","volume":"23","author":[{"given":"GE","family":"Fragoulis","sequence":"first","affiliation":[{"name":"Institute of Infection, Immunity and Inflammation University of Glasgow Glasgow UK"},{"name":"Pathophysiology Department School of Medicine University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Zampeli","sequence":"additional","affiliation":[{"name":"Pathophysiology Department School of Medicine University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HM","family":"Moutsopoulos","sequence":"additional","affiliation":[{"name":"Pathophysiology Department School of Medicine University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2014.891964"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206605"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12641"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.72"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100383"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283413011"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25387"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27435"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39132"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3810"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0698-y"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.089169"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.03.034"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22216"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-012-0905-z"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.07.007"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2016.1148225"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146738"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2015.1072296"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0751-x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes358"},{"key":"e_1_2_8_23_1","first-page":"724","article-title":"IgG4\u2010related disease: a rheumatologist's perspective","volume":"32","author":"Soliotis F","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1104650"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2016.1154605"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.236"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-011-0571-z"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39205"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.33386"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02285209"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.12526","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.12526","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.12526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T09:33:57Z","timestamp":1696152837000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.12526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,14]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/odi.12526"],"URL":"https:\/\/doi.org\/10.1111\/odi.12526","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,14]]}}}