{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T18:45:57Z","timestamp":1778352357206,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T00:00:00Z","timestamp":1468886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>The large number of diseases occurring when desmosome constituents are impaired provides striking evidence for the key role of desmosomes in maintaining tissue integrity. A detailed understanding of the molecular alterations causing desmosomal dysfunction has, in turn, underpinned the development of novel diagnostic tools. This has salient clinical implications for dentists and oral medicine practitioners because the majority of desmosomal diseases affect the oral cavity. In the present article, we review the autoimmune, infectious, genetic, and neoplastic diseases that target the desmosome, with particular emphasis on clinical manifestations, diagnostic pathways, and relevant laboratory investigations.<\/jats:p>","DOI":"10.1111\/odi.12527","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T20:01:03Z","timestamp":1466625663000},"page":"157-167","source":"Crossref","is-referenced-by-count":14,"title":["Desmosomes in disease: a guide for clinicians"],"prefix":"10.1111","volume":"23","author":[{"given":"A","family":"Celentano","sequence":"first","affiliation":[{"name":"Melbourne Dental School and Oral Health CRC University of Melbourne Melbourne Vic. Australia"},{"name":"Department of Neurosciences Reproductive and Odontostomatological Sciences Federico II University of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Cirillo","sequence":"additional","affiliation":[{"name":"Melbourne Dental School and Oral Health CRC University of Melbourne Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.3.447-475.2001"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.86.524"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.390"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/81385"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/504393"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2009.07.002"},{"key":"e_1_2_10_9_1","first-page":"110","article-title":"Delle cellule cigliate, del reticolo Malpighiano dell'epidermide","volume":"190","author":"Bizzozero G","year":"1864","journal-title":"Ann Univ Med"},{"key":"e_1_2_10_10_1","first-page":"1019","article-title":"Molecular diagnosis of autoimmune skin diseases","volume":"55","author":"Chiorean R","year":"2014","journal-title":"Rom J Morphol Embryol"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/CHC.S59510"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-009-0139-7"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02585.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01899.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12162"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203536"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/15419061.2015.1039642"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00516.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2011.01.013"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057587"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/15419061.2014.943397"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2011.07809_suppl.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01011-12"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.05.002"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2165\/11530050-000000000-00000"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23311.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.70.933"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.2174\/15665240113136660079"},{"key":"e_1_2_10_29_1","first-page":"586","volume-title":"Fitzpatrick's Dermatology in General Medicine","author":"Payne AS","year":"2012"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2013.01.004"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2739"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012250"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-015-2155-2"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.561654"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13025"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.14.8064"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1201-1076"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-4-10"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2012.00921.x"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.50"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.12527","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.12527","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.12527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T09:34:01Z","timestamp":1696152841000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.12527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,19]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/odi.12527"],"URL":"https:\/\/doi.org\/10.1111\/odi.12527","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,19]]}}}